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Uramustine Chemical Structure
|Product name: Uramustine|
|Cat. No.: HY-13544|
Uramustine is an antineoplastic agent with of 5.1μM in K562 human leukemia cell line.
IC50 value: 5.1 μM
Target: DNA alkylator/crosslinker
Uramustine is a chemotherapy drug which belongs to the class of alkylating agents. It is used in lymphatic malignancies such as non-Hodgkin's lymphoma. It works by damaging DNA, primarily in cancer cells that preferentially take up the uracil due to their need to make nucleic acids during their rapid cycles of cell division. The DNA damage leads to apoptosis of the affected cells.
|M.Wt||252.1||Storage||Please store the product under the recommended conditions in the Certificate of Analysis.|
|Solvent & Solubility||
DMSO: ≥ 29 mg/mL
|1 mg||5 mg||10 mg|
|1 mM||3.9667 mL||19.8334 mL||39.6668 mL|
|5 mM||0.7933 mL||3.9667 mL||7.9334 mL|
|10 mM||0.3967 mL||1.9833 mL||3.9667 mL|
Busulfan is a bifunctional alkylating agent.
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Carmustine is a cell-cycle phase nonspecific alkylating antineoplastic agent.
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Fotemustine (S 10036) is a nitrosourea alkylating agent approved for use in the treatment of metastasising melanoma.
Ifosfamide is a nitrogen mustard alkylating agent used in the treatment of cancer.
Lomustine (CCNU) is an alkylating nitrosourea compound used in chemotherapy.
Melphalan(Sarcolysin; L-PAM) is a chemotherapy drug belonging to the class of nitrogen mustard alkylating agents; attaches the alkyl group to the guanine base of DNA.
Mitomycin C is a DNA crosslinking agent that inhibits DNA synthesis and induces apoptosis in a variety of cells.
Oxaliplatin inhibits DNA synthesis by conforming DNA adducts.