1. Metabolic Enzyme/Protease
  2. Acyltransferase
  3. FCE 28654

FCE 28654 

Cat. No.: HY-U00369
Handling Instructions

FCE 28654 is an inhibitor of acylCoA: cholesterol acyltransferase (ACAT), weakly inhibiting ACAT in microsomes from rabbit aorta and intestine, and monkey liver, with IC50s of 2.55, 1.08 and 5.69 μM, respcetively.

For research use only. We do not sell to patients.

FCE 28654 Chemical Structure

FCE 28654 Chemical Structure

CAS No. : 169474-77-5

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Description

FCE 28654 is an inhibitor of acylCoA: cholesterol acyltransferase (ACAT), weakly inhibiting ACAT in microsomes from rabbit aorta and intestine, and monkey liver, with IC50s of 2.55, 1.08 and 5.69 μM, respcetively.

IC50 & Target

IC50: 2.55 μM (ACAT, Rabbit aorta), 1.08 μM (ACAT, Rabbit intestine), 5.69 μM (ACAT, Monkey liver)[1]

In Vitro

FCE 28654 is an inhibitor of ACAT, weakly inhibiting ACAT in microsomes from rabbit aorta and intestine, and monkey liver, with IC50s of 2.55, 1.08 and 5.69 μM, respcetively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

FCE 28654 (15 mg/kg, p.o.) dramatically decreases blood cholesterol and modifies the hepatic cholesterol pattern via enhancing the free/esterified cholesterol ratio, in hypercholesterolemic rats. FCE 28654 (100 mg/kg, p.o.) also reduces microsomal ACAT activity rat plasma[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

506.53

Formula

C₂₅H₃₅N₂O₇P

CAS No.

169474-77-5

SMILES

CC(C)C(C=CC=C1C(C)C)=C1NC(NCC2(C3=CC=C(OP(O)(O)=O)C=C3)O[[email protected]](C)[[email protected]@H](C)O2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

FCE 28654FCE28654FCE-28654AcyltransferaseDiacylglycerol acyltransferaseDiglyceride acyltransferaseacyl-CoA:cholesterol acyltransferasemono- acylglycerol acyltransferaseInhibitorinhibitorinhibit

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FCE 28654
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HY-U00369
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