1. MAPK/ERK Pathway
    Stem Cell/Wnt
  2. ERK
  3. Ulixertinib

Ulixertinib (Synonyms: BVD-523; VRT752271)

製品番号: HY-15816 純度: 99.92%
取扱説明書

Ulixertinib (BVD-523; VRT752271) is a potent, orally active, highly selective, ATP-competitive and reversible covalent inhibitor of ERK1/2 kinases, with an IC50 of <0.3 nM against ERK2. Ulixertinib (BVD-523; VRT752271) inhibits the phosphorylated ERK2 (pERK) and downstream kinase RSK (pRSK) in an A375 melanoma cell line.

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Ulixertinib 構造式

Ulixertinib 構造式

CAS 番号 : 869886-67-9

容量 価格(税別) 在庫状況 数量
無料サンプル (0.5-1 mg)   今すぐ申し込む  
10 mM * 1  mL in DMSO USD 77 在庫あり
Estimated Time of Arrival: December 31
5 mg USD 70 在庫あり
Estimated Time of Arrival: December 31
10 mg USD 110 在庫あり
Estimated Time of Arrival: December 31
50 mg USD 250 在庫あり
Estimated Time of Arrival: December 31
100 mg USD 450 在庫あり
Estimated Time of Arrival: December 31
200 mg USD 650 在庫あり
Estimated Time of Arrival: December 31
500 mg   お問い合わせ  
1 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

カスタマーレビュー

Based on 8 publication(s) in Google Scholar

Other Forms of Ulixertinib:

Top Publications Citing Use of Products

    Ulixertinib purchased from MCE. Usage Cited in: Innate Immun. 2020 May 26;1753425920918911.

    The protein levels of p-ERK1/2, ERK1/2, p-RSK, and RSK are measured by Western blotting.

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    製品説明

    Ulixertinib (BVD-523; VRT752271) is a potent, orally active, highly selective, ATP-competitive and reversible covalent inhibitor of ERK1/2 kinases, with an IC50 of <0.3 nM against ERK2. Ulixertinib (BVD-523; VRT752271) inhibits the phosphorylated ERK2 (pERK) and downstream kinase RSK (pRSK) in an A375 melanoma cell line[1][2].

    IC50 & Target[2]

    ERK2

    0.3 nM (IC50, at KM ATP (60 μM))

    ERK1

     

    体外実験

    Combined Ulixertinib (BVD-523; 10, 20, 30 μM; 48 hours) and VS-5584 treatment causes significant induction of cell death in human pancreatic cancer (HPAC) cells in PDAC cell lines BxPC-3, MIAPaCa-2, and CFPAC-1[3].

    体内実験

    In the pharmacokinetic study, the sensitivity and specificity of the assay are found to be sufficient for accurately characterizing the plasma pharmacokinetics of Ulixertinib (VRT752271) in Balb/C mice[2].

    臨床実験
    分子量

    433.33

    分子式

    C₂₁H₂₂Cl₂N₄O₂

    CAS 番号

    869886-67-9

    SMILES

    O=C(C1=CC(C2=CC(NC(C)C)=NC=C2Cl)=CN1)N[[email protected]@H](C3=CC=CC(Cl)=C3)CO

    輸送条件

    Room temperature in continental US; may vary elsewhere.

    保管条件
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    溶剤 & 溶解度
    体外: 

    DMSO : 100 mg/mL (230.77 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.3077 mL 11.5386 mL 23.0771 mL
    5 mM 0.4615 mL 2.3077 mL 4.6154 mL
    10 mM 0.2308 mL 1.1539 mL 2.3077 mL
    *Please refer to the solubility information to select the appropriate solvent.
    体内:
    • 1.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (5.77 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (5.77 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    参考文献

    純度: 99.92%

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    The molarity calculator equation

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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

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    × = ×
    C1   V1   C2   V2

    Keywords:

    UlixertinibBVD-523VRT752271BVD523BVD 523VRT 752271VRT-752271ERKExtracellular signal regulated kinasesInhibitorinhibitorinhibit

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    製品名:
    Ulixertinib
    製品番号:
    HY-15816
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