1. Epigenetics
  2. Protein Arginine Deiminase

YW3-56 

Cat. No.: HY-112903
Handling Instructions

YW3-56 is a potent peptidylarginine deiminase (PAD) inhibitor, with an IC50 of 1-5 μM for PAD4.

For research use only. We do not sell to patients.

YW3-56 Chemical Structure

YW3-56 Chemical Structure

CAS No. : 1374311-17-7

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Description

YW3-56 is a potent peptidylarginine deiminase (PAD) inhibitor, with an IC50 of 1-5 μM for PAD4.

IC50 & Target

IC50: 1-5 μM (PAD4)[1].

In Vitro

Compared with Cl-amidine, YW3-56 shows >60-fold increase in cell growth inhibition efficacy (IC50 about 2.5 μM) but only 5-fold increase in PAD4 inhibition (IC sub>50 about 1-5 μM). At 2-4 μM concentrations, YW3-56 displays mainly cytostatic effects by slowing cell division, whereas at higher concentrations, it exerts cytotoxic effects by altering cell morphology and killing cells[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0242 mL 10.1208 mL 20.2417 mL
5 mM 0.4048 mL 2.0242 mL 4.0483 mL
10 mM 0.2024 mL 1.0121 mL 2.0242 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

494.03

Formula

C₂₇H₃₂ClN₅O₂

CAS No.

1374311-17-7

SMILES

O=C(C1=CC=C2C=C(N(C)C)C=CC2=C1)N[[email protected]](C(NCC3=CC=CC=C3)=O)CCCNC(CCl)=N

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
YW3-56
Cat. No.:
HY-112903
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YW3-56

Cat. No.: HY-112903