1. Metabolic Enzyme/Protease
  2. FXR

(-)-PX20606 trans isomer (Synonyms: (-)-PX-102 trans isomer; (-)-PX-104)

Cat. No.: HY-100443B Purity: 98.39%
Handling Instructions

(-)-PX20606 trans isomer is a FXR agonist with EC50s of 18 and 29 nM for FXR in FRET and M1H assay, respectively.

For research use only. We do not sell to patients.

(-)-PX20606 trans isomer Chemical Structure

(-)-PX20606 trans isomer Chemical Structure

CAS No. : 1268244-88-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 2014 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
1 mg USD 420 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
2 mg USD 660 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
5 mg   Get quote  
10 mg   Get quote  

* Please select Quantity before adding items.

Other Forms of (-)-PX20606 trans isomer:

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

(-)-PX20606 trans isomer is a FXR agonist with EC50s of 18 and 29 nM for FXR in FRET and M1H assay, respectively.

IC50 & Target

EC50: 18 nM (FXR in FRET assay), 29 nM (FXR in M1H assay)[1]

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 1.8023 mL 9.0114 mL 18.0229 mL
5 mM 0.3605 mL 1.8023 mL 3.6046 mL
10 mM 0.1802 mL 0.9011 mL 1.8023 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

554.85

Formula

C₂₉H₂₂Cl₃NO₄

CAS No.

1268244-88-7

SMILES

ClC1=C(C2=NOC(C3CC3)=C2COC4=CC=C([[email protected]@H]5C[[email protected]]5C6=CC=C(C(O)=O)C=C6)C(Cl)=C4)C(Cl)=CC=C1.[(-)].[Rotation]

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
(-)-PX20606 trans isomer
Cat. No.:
HY-100443B
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