1. Metabolic Enzyme/Protease
    Autophagy
  2. FXR
    Autophagy
  3. (-)-PX20606 trans isomer

(-)-PX20606 trans isomer (Synonyms: (-)-PX-102 trans isomer; (-)-PX-104)

Cat. No.: HY-100443B Purity: 98.39%
Handling Instructions

(-)-PX20606 trans isomer is a FXR agonist with EC50s of 18 and 29 nM for FXR in FRET and M1H assay, respectively.

For research use only. We do not sell to patients.

(-)-PX20606 trans isomer Chemical Structure

(-)-PX20606 trans isomer Chemical Structure

CAS No. : 1268244-88-7

Size Price Stock Quantity
1 mg USD 420 In-stock
Estimated Time of Arrival: December 31
2 mg USD 660 In-stock
Estimated Time of Arrival: December 31
5 mg   Get quote  
10 mg   Get quote  

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Other Forms of (-)-PX20606 trans isomer:

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Description

(-)-PX20606 trans isomer is a FXR agonist with EC50s of 18 and 29 nM for FXR in FRET and M1H assay, respectively.

IC50 & Target

EC50: 18 nM (FXR in FRET assay), 29 nM (FXR in M1H assay)[1]

Molecular Weight

554.85

Formula

C₂₉H₂₂Cl₃NO₄

CAS No.

1268244-88-7

SMILES

ClC1=C(C2=NOC(C3CC3)=C2COC4=CC=C([[email protected]@H]5C[[email protected]]5C6=CC=C(C(O)=O)C=C6)C(Cl)=C4)C(Cl)=CC=C1.[(-)].[Rotation]

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

Ethanol : ≥ 50 mg/mL (90.11 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8023 mL 9.0114 mL 18.0229 mL
5 mM 0.3605 mL 1.8023 mL 3.6046 mL
10 mM 0.1802 mL 0.9011 mL 1.8023 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% EtOH    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.51 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% EtOH    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.51 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
(-)-PX20606 trans isomer
Cat. No.:
HY-100443B
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