1. Cell Cycle/DNA Damage
    PI3K/Akt/mTOR
  2. DNA-PK
  3. (R)-Nedisertib

(R)-Nedisertib (Synonyms: (R)-M3814)

Cat. No.: HY-101570A
Handling Instructions

(R)-Nedisertib ((R)-M3814) is a less active R-enantiomer of Nedisertib, with an IC50 in the range of 7-30 nM for DNA-PK.

For research use only. We do not sell to patients.

(R)-Nedisertib Chemical Structure

(R)-Nedisertib Chemical Structure

CAS No. : 1637542-32-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 275 In-stock
Estimated Time of Arrival: December 31
5 mg USD 250 In-stock
Estimated Time of Arrival: December 31
10 mg USD 350 In-stock
Estimated Time of Arrival: December 31
25 mg USD 650 In-stock
Estimated Time of Arrival: December 31
50 mg USD 950 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of (R)-Nedisertib:

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Description

(R)-Nedisertib ((R)-M3814) is a less active R-enantiomer of Nedisertib, with an IC50 in the range of 7-30 nM for DNA-PK[1].

IC50 & Target[1]

DNA-PK

7-30 nM (IC50)

In Vitro

Rac-Nedisertib (Compound 135) less actively inhibits DNA-PK, with an IC50 in the range of 7-30 nM[1].

Molecular Weight

481.91

Formula

C₂₄H₂₁ClFN₅O₃

CAS No.

1637542-32-5

SMILES

ClC1=C([[email protected]@H](O)C2=NN=C(OC)C=C2)C=C(C3=C4C=CC(N5CCOCC5)=CC4=NC=N3)C(F)=C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (207.51 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0751 mL 10.3754 mL 20.7508 mL
5 mM 0.4150 mL 2.0751 mL 4.1502 mL
10 mM 0.2075 mL 1.0375 mL 2.0751 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.19 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.19 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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(R)-Nedisertib
Cat. No.:
HY-101570A
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