1. GPCR/G Protein
    Neuronal Signaling
  2. CGRP Receptor

CGRP antagonist 1 

Cat. No.: HY-112262
Handling Instructions

CGRP antagonist 1 is a highly potent CGRP receptor antagonist with a Ki and IC50 of 35 and 57 nM, respectively.

For research use only. We do not sell to patients.

CGRP antagonist 1 Chemical Structure

CGRP antagonist 1 Chemical Structure

CAS No. : 1123757-49-2

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

CGRP antagonist 1 is a highly potent CGRP receptor antagonist with a Ki and IC50 of 35 and 57 nM, respectively.

IC50 & Target

IC50: 57 nM (CGRP receptor)[1]

Ki: 35 nM(CGRP receptor)[1]

In Vitro

CGRP antagonist 1 is compound 20[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0221 mL 10.1104 mL 20.2208 mL
5 mM 0.4044 mL 2.0221 mL 4.0442 mL
10 mM 0.2022 mL 1.0110 mL 2.0221 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

494.54

Formula

C₂₉H₂₆N₄O₄

CAS No.

1123757-49-2

SMILES

O=C(NC1=CC2=C(C[[email protected]@]3(C4=CC=CN=C4NC3=O)C2)C=C1)CN5C(C6(CCOCC6)C7=C5C=CC=C7)=O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
CGRP antagonist 1
Cat. No.:
HY-112262
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CGRP antagonist 1

Cat. No.: HY-112262