1. NF-κB
    Antibody-drug Conjugate/ADC Related
  2. NF-κB
    ADC Cytotoxin
  3. Aeruginosin 865

Aeruginosin 865 

Cat. No.: HY-130994
Handling Instructions

Aeruginosin 865, isolated from terrestrial cyanobacterium Nostoc sp. Lukešová 30/93, is the first aeruginosin-type peptide containing both a fatty acid and a carbohydrate moiety. Aeruginosin 865 inhibits translocation of NF-kB to the nucleus. Aeruginosin 865 has anti-inflammatory effect

For research use only. We do not sell to patients.

Aeruginosin 865 Chemical Structure

Aeruginosin 865 Chemical Structure

CAS No. : 1611990-01-2

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Aeruginosin 865, isolated from terrestrial cyanobacterium Nostoc sp. Lukešová 30/93, is the first aeruginosin-type peptide containing both a fatty acid and a carbohydrate moiety. Aeruginosin 865 inhibits translocation of NF-kB to the nucleus. Aeruginosin 865 has anti-inflammatory effect[1]

In Vitro

Aeruginosin 865 (pretreatment with 0.1-100 μg/mL) shows significant inhibition of IL-8 (EC50=3.5 μg/mL) and ICAM-1 (EC50=50.0 μg/mL) in hTNF-α-stimulated HLMVECs in a concentration-dependent manner. Aeruginosin 865 does not affect cell viability, even at much higher concentration in HeLa, HepG2 cells[1].
Aeruginosin 865 (100-200 μM) shows high-dose cytotoxicity in Mouse fibrosarcoma cells and with no cytotoxic effect in NIH/3T3 cells[2].
.

Molecular Weight

864.98

Formula

C₄₁H₆₄N₆O₁₄

CAS No.

1611990-01-2

SMILES

O=C([[email protected]@H]1[[email protected]@H](O)[[email protected]](O)[[email protected]](O)[[email protected]](O[[email protected]@H]2[[email protected]@H](OC(CCCCC)=O)C[[email protected]@]3([H])C[[email protected]](C(NCCCCNC(N)=N)=O)N(C([[email protected]](NC([[email protected]](O)CC4=CC=C(O)C=C4)=O)CC(C)C)=O)[[email protected]@]3([H])C2)O1)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Aeruginosin 865Aeruginosin865Aeruginosin-865NF-κBADC CytotoxinNuclear factor-κBNuclear factor-kappaBaeruginosin-typepeptidetranslocationNF-kBnucleusanti-inflammatoryIL-8ICAM-1HLMVECsNIH/3T3Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Aeruginosin 865
Cat. No.:
HY-130994
Quantity:
MCE Japan Authorized Agent: