1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. GABA Receptor
    Chloride Channel
  3. Afoxolaner

Afoxolaner 

Cat. No.: HY-16974 Purity: 99.53%
Handling Instructions

Afoxolaner is an orally active isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect γ-aminobutyric acid receptor (GABA) and glutamate receptors, inhibiting GABA & glutamate-regulated uptake of chloride ions, resulting in excess neuronal stimulation and death of the arthropod.

For research use only. We do not sell to patients.

Afoxolaner Chemical Structure

Afoxolaner Chemical Structure

CAS No. : 1093861-60-9

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 83 In-stock
Estimated Time of Arrival: December 31
10 mg USD 120 In-stock
Estimated Time of Arrival: December 31
25 mg USD 240 In-stock
Estimated Time of Arrival: December 31
50 mg USD 360 In-stock
Estimated Time of Arrival: December 31
100 mg USD 610 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Afoxolaner is an orally active isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect γ-aminobutyric acid receptor (GABA) and glutamate receptors, inhibiting GABA & glutamate-regulated uptake of chloride ions, resulting in excess neuronal stimulation and death of the arthropod[1][2].

In Vivo

A single oral treatment with a dose approaching the minimum effective dose of afoxolaner (2.5mg/kg) eliminated the pre-existing infestations of I. scapularis ticks and controlled weekly re-infestations, with efficacy between 98% and 100% recorded until Day 23 and 94% at Day 30[1].

Molecular Weight

625.87

Formula

C₂₆H₁₇ClF₉N₃O₃

CAS No.

1093861-60-9

SMILES

O=C(C1=C2C=CC=CC2=C(C3=NOC(C(F)(F)F)(C4=CC(C(F)(F)F)=CC(Cl)=C4)C3)C=C1)NCC(NCC(F)(F)F)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 250 mg/mL (399.44 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5978 mL 7.9889 mL 15.9778 mL
5 mM 0.3196 mL 1.5978 mL 3.1956 mL
10 mM 0.1598 mL 0.7989 mL 1.5978 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.25 mg/mL (3.59 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.25 mg/mL (3.59 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

AfoxolanerGABA ReceptorChloride ChannelGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorCl− ChannelsisoxazolineinsecticideacaricideIxodesscapularisinsectdogarthropodInhibitorinhibitorinhibit

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Afoxolaner
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HY-16974
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