1. Metabolic Enzyme/Protease
  2. Neprilysin

AHU-377 hemicalcium salt (Synonyms: Sacubitril hemicalcium salt)

Cat. No.: HY-15407A Purity: 99.61%
Handling Instructions

AHU-377 hemicalcium salt is a potent NEP inhibitor with an IC50 of 5 nM. AHU-377 is a component of the heart failure medicine LCZ696.

For research use only. We do not sell to patients.
AHU-377 hemicalcium salt Chemical Structure

AHU-377 hemicalcium salt Chemical Structure

CAS No. : 1369773-39-6

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
5 mg USD 60 In-stock
10 mg USD 72 In-stock
50 mg USD 132 In-stock
100 mg USD 192 In-stock
500 mg USD 360 In-stock
1 g USD 552 In-stock
5 g   Get quote  
10 g   Get quote  

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Other Forms of AHU-377 hemicalcium salt:

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation


AHU-377 hemicalcium salt is a potent NEP inhibitor with an IC50 of 5 nM. AHU-377 is a component of the heart failure medicine LCZ696.

IC50 & Target

IC50: 5 nM (NEP)[1]

In Vitro

LCZ696 is a single molecule that is comprised of molecular moieties of valsartan, an ARB, and AHU377, a neprilysin inhibitor (1:1 ratio). AHU377 is converted by enzymatic cleavage of the ethyl ester into the active neprilysin inhibiting metabolite LBQ657[2]. The inactive NEPi precursor, AHU377, does not inhibit collagen accumulation in fibroblasts nor cardiac myocyte hypertrophy. In cardiac fibroblasts, the active NEPi LBQ657 had no discernible effects. In contrast, LBQ657 modestly inhibits cardiac myocyte hypertrophy[3].

In Vivo

In humans, AHU377 (tmax 0.5-1.1 h) are absorbed quickly. AHU377 is converted rapidly into LBQ657 with its tmax being reached in 1.9-3.5 h. Mean t1/2 values for the biologically active LBQ657 is 9.9-11.1 h[2].In vehicle-treated dogs, ANF increases urinary sodium excretion from 17.3±3.6 to 199.5±18.4 pequivkglmin. This effect is potentiated significantly in animals which receive AHU377. Urinary volume is also potentiated in animals which receive an iv administration of AHU377[1].

Clinical Trial
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.3228 mL 11.6139 mL 23.2277 mL
5 mM 0.4646 mL 2.3228 mL 4.6455 mL
10 mM 0.2323 mL 1.1614 mL 2.3228 mL
Please refer to the solubility information to select the appropriate solvent.
Molecular Weight







O=C(CCC([O-])=O)N[[email protected]](CC1=CC=C(C2=CC=CC=C2)C=C1)C[[email protected]@H](C)C(OCC)=O.[0.5Ca2+]

Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 54 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 99.61%

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