1. Metabolic Enzyme/Protease
  2. Cytochrome P450
  3. 17-ODYA

17-ODYA 

Cat. No.: HY-101016 Purity: ≥95.0%
Handling Instructions

17-ODYA is a CYP450 ω-hydroxylase inhibitor. 17-ODYA is also a potent inhibitor (IC50<100 nM) of the formation of 20-hydroxyeicosatetraenoic acid (20-HETE), epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids by rat renal cortical microsomes incubated with arachidonic acid. 17-ODYA completely attenuates the isoproterenol (ISO)-induced apoptosis, and necrosis in cultured cardiomyocytes.

For research use only. We do not sell to patients.

17-ODYA Chemical Structure

17-ODYA Chemical Structure

CAS No. : 34450-18-5

Size Price Stock Quantity
5 mg USD 120 In-stock
Estimated Time of Arrival: December 31
10 mg USD 205 In-stock
Estimated Time of Arrival: December 31
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100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

17-ODYA is a CYP450 ω-hydroxylase inhibitor. 17-ODYA is also a potent inhibitor (IC50<100 nM) of the formation of 20-hydroxyeicosatetraenoic acid (20-HETE), epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids by rat renal cortical microsomes incubated with arachidonic acid. 17-ODYA completely attenuates the isoproterenol (ISO)-induced apoptosis, and necrosis in cultured cardiomyocytes[1][2][3].

IC50 & Target[1]

CYP450 ω-hydroxylase

 

In Vivo

Infusion of 17-ODYA (16.5 nmol/min) directly into the renal cortical interstitium of rats produced a diuresis and a natriuresis which were associated with an increase in renal papillary blood flow in the absence of changes in renal blood flow, cortical blood flow or glomerular filtration rate[2].
17-ODYA (0.28 mg/kg; intracoronary; infusion for 2 to 3 minutes; dogs) markedly inhibits 20-HETE production during ischemia-reperfusion and produces a profound reduction in myocardial infarct size[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

280.45

Formula

C18H32O2

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (89.14 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5657 mL 17.8285 mL 35.6570 mL
5 mM 0.7131 mL 3.5657 mL 7.1314 mL
10 mM 0.3566 mL 1.7828 mL 3.5657 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.5 mg/mL (8.91 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.91 mM); Clear solution

*All of the co-solvents are available by MCE.
References
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Product Name:
17-ODYA
Cat. No.:
HY-101016
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