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  2. Bacterial
  3. Ancremonam

Ancremonam (Synonyms: BOS-228; LYS-228)

Cat. No.: HY-120129
Handling Instructions

Ancremonam (LYS-228) is a low toxicity, potent and single-agent monobactam antibiotic targeting penicillin binding protein 3 with potent activity against Enterobacteriaceae. Ancremonam kills bacteria by inhibiting cell wall synthesis through covalent modification of the active-site serine of penicillin binding protein 3.

For research use only. We do not sell to patients.

Ancremonam Chemical Structure

Ancremonam Chemical Structure

CAS No. : 1810051-96-7

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Description

Ancremonam (LYS-228) is a low toxicity, potent and single-agent monobactam antibiotic targeting penicillin binding protein 3 with potent activity against Enterobacteriaceae. Ancremonam kills bacteria by inhibiting cell wall synthesis through covalent modification of the active-site serine of penicillin binding protein 3[1][2][3].

In Vitro

Ancremonam is a single-agent monobactam that is effective against Enterobacteriaceae strains, including those expressing extended-spectrum -lactamases (ESBLs), metallo--lactamases (MBLs) and serine -lactamases (SBLs). Ancremonam MIC values for 37 strains encoded the following ESBLs, such as TEM-10, TEM-12, TEM-52, ranged from ≤0.06 to 8 μg/mL, with MIC50 and MIC90 values of 0.12 and 1 μg/mL, respectively[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

518.48

Formula

C₁₆H₁₈N₆O₁₀S₂

CAS No.
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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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