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Androgen receptor antagonist 2 

Cat. No.: HY-145451
Handling Instructions

Androgen receptor antagonist 2 (example 12) is an androgen receptor antagonist. Androgen receptor antagonist 2 can be used for prostate cancer and male hair loss research.

For research use only. We do not sell to patients.

Androgen receptor antagonist 2 Chemical Structure

Androgen receptor antagonist 2 Chemical Structure

CAS No. : 1272719-00-2

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Description

Androgen receptor antagonist 2 (example 12) is an androgen receptor antagonist. Androgen receptor antagonist 2 can be used for prostate cancer and male hair loss research[1].

In Vitro

Androgen receptor antagonist 2 (example 12) inhibits PSA production with an IC50 of 0.28 μM in LNCaP cells[1].
Androgen receptor antagonist 2 (2.5 μM, 48 h) inhibits prostate cancer cells viability[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: LNCaP and 22RV1 cells
Concentration: 2.5 μM
Incubation Time: 48 h
Result: Inhibited cell viability with inhibition rates of 86% and 61% for LNCaP and 22RV1 cells, respectively.
In Vivo

Androgen receptor antagonist 2 (example 12) (0.2% and 1% concentration, 20 mL/mouse; topical application; twice daily for 4 weeks) promotes hair growth in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six-to 8-wk-old male C57BL/6 mice in the telogen stage of the hair cycle, weighing 15-20 g[1]
Dosage: 0.2% and 1% concentration, 20 mL/mouse (0.04 and 0.2 mg/mouse)
Administration: Topical application, twice daily for 4 weeks
Result: Stimulated hair growth in dose dependent patterns.
Molecular Weight

482.43

Formula

C21H15F5N4O2S

CAS No.
SMILES

N#CC1=CC=C(N2C(C(C)(C)N(C2=S)C3=CC=C(C(F)=C3)C(NC)=O)=O)C(F)=C1C(F)(F)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Androgen receptor antagonist 2
Cat. No.:
HY-145451
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