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Androgen receptor modulators 1 

Cat. No.: HY-101781
Handling Instructions

Androgen receptor modulators 1 is a selective androgen receptor modulator (SARM). Androgen receptor modulators 1 has strong agonistic activities with an EC50 of 4.7 nM.

For research use only. We do not sell to patients.

Androgen receptor modulators 1 Chemical Structure

Androgen receptor modulators 1 Chemical Structure

CAS No. : 1114546-03-0

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Androgen receptor modulators 1 is a selective androgen receptor modulator (SARM). Androgen receptor modulators 1 has strong agonistic activities with an EC50 of 4.7 nM[1].

IC50 & Target

EC50: 4.7 nM (SARM)[1]

In Vivo

Androgen receptor modulators 1 (Compounds 2f) induces sexual behavior at the minimal dose (0.5 mg/kg/day, qd, po, 7 days). It could act as androgen agonist on the CNS[1].

Androgen receptor modulators 1 shows good metabolic stabilities with little species difference between rat, dog, mouse, monkey and human[1].

Animal Model: 8-weeks-old castrated male SD rats[1]
Dosage: 0.15, 0.50, 1.5, 5.0, 15 mg/kg
Administration: Oral, daily, 7 day
Result: After treatment with Androgen receptor modulators 1 for 3 weeks, sexual behavior induction is confirmed by the pseudopregnancy rate in female rats. It induces sexual behavior at the minimal dose (0.5 mg/kg/day, qd, po)[1].
Animal Model: Male Sprague−Dawley rats of 8 weeks[1]
Dosage: 1 mg/kg (i.v.) or 10 mg/kg (oral)
Administration: i.v. or oral 15, and 30 min and at 1, 2, 4, 8, 12, and 24 h
Result: Androgen receptor modulators 1 shows good systemic exposure and oral bioavailability (76%), and the low CL demonstrates that it is metabolized and excreted very slowly[1].
Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3528 mL 16.7639 mL 33.5278 mL
5 mM 0.6706 mL 3.3528 mL 6.7056 mL
10 mM 0.3353 mL 1.6764 mL 3.3528 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

298.26

Formula

C₁₄H₁₃F₃N₂O₂

CAS No.

1114546-03-0

SMILES

O=C1C[[email protected]](O)[[email protected]](CC)N1C2=CC(C(F)(F)F)=C(C#N)C=C2

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Androgen receptor modulators 1
Cat. No.:
HY-101781
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Androgen receptor modulators 1

Cat. No.: HY-101781