2. Anti-infection
  3. Bacterial
  4. 22-((4-Methoxyphenyl)urea-1-yl)-22-deoxypleuromutilin

22-((4-Methoxyphenyl)urea-1-yl)-22-deoxypleuromutilin 

Cat. No.: HY-146756
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22-((4-Methoxyphenyl)urea-1-yl)-22-deoxypleuromutilin (compound 6n) is an antibacterial pleuromutilin derivative against Gram-positive pathogens (GPPs) and Mycoplasma pneumoniae.

For research use only. We do not sell to patients.

22-((4-Methoxyphenyl)urea-1-yl)-22-deoxypleuromutilin Chemical Structure

22-((4-Methoxyphenyl)urea-1-yl)-22-deoxypleuromutilin Chemical Structure

CAS No. : 2780409-77-8

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22-((4-Methoxyphenyl)urea-1-yl)-22-deoxypleuromutilin Related Antibodies

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Description

22-((4-Methoxyphenyl)urea-1-yl)-22-deoxypleuromutilin (compound 6n) is an antibacterial pleuromutilin derivative against Gram-positive pathogens (GPPs) and Mycoplasma pneumoniae[1].

In Vitro

22-((4-Methoxyphenyl)urea-1-yl)-22-deoxypleuromutilin (compound 6n) (0.0625 -128 µg/mL, 8 h) shows antibacterial activity with MICs of 0.0625, 0.5, 8, 0.125, 0.0625, and 0.5 µg/mL against MSSA, MRSA, E.faecium, M.pneumonia (ATCC15331), M.pneumonia (ATCC29342), and M.pneumonia (resistant strain, clinically isolated strain), respectively[1].
22-((4-Methoxyphenyl)urea-1-yl)-22-deoxypleuromutilin (0-10 µg/mL, 72 h) shows low cytotoxicity in human cancer cells[1].
22-((4-Methoxyphenyl)urea-1-yl)-22-deoxypleuromutilin exhibits good ADMET properties with high LogS, attractive ALogP, low PPB, non-Ames toxic, and non-carcinogenic[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

22-((4-Methoxyphenyl)urea-1-yl)-22-deoxypleuromutilin Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: Five human cancer cell lines (HeG2, U87, HGC27, HT29 and MCF2)
Concentration: 0-10 µg/mL
Incubation Time: 72 h
Result: Showed low cytotoxicity ((IC50>10 μmol/L).
Molecular Weight

526.66

Formula

C30H42N2O6
CAS No.
SMILES

C[C@]1(C[C@H]([C@@]([C@H](C)CC2)(C)[C@H](C(CC3)=O)[C@@]23[C@H]([C@@H]1O)C)OC(CNC(NC4=CC=C(C=C4)OC)=O)=O)C=C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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22-((4-Methoxyphenyl)urea-1-yl)-22-deoxypleuromutilin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

22-((4-Methoxyphenyl)urea-1-yl)-22-deoxypleuromutilin2780409-77-8BacterialGram-positiveMycoplasma pneumoniaeStaphylococcus aureusStaphylococcus epidermidis Enterococcus faeciumHeG2U87HGC27HT29MCF2Inhibitorinhibitorinhibit

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22-((4-Methoxyphenyl)urea-1-yl)-22-deoxypleuromutilin
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