1. Metabolic Enzyme/Protease
  2. Mitochondrial Metabolism
  3. Antimycin A3

Antimycin A3 

Cat. No.: HY-105755
Handling Instructions

Antimycin A3, is an antibiotic isolated from a number of Streptomyces species, shows antifungal activities. Antimycin A3 is a potent inhibitor of respiration. Antimycin A3 inhibits the electron transfer activity of ubiquinol-cytochrome c oxidoreductase and prevents the growth of human cancer cells. Antimycin A3 also inhibits ATP-citrate lyase with a Ki value of 60.1 µM.

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Antimycin A3 Chemical Structure

Antimycin A3 Chemical Structure

CAS No. : 522-70-3

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Description

Antimycin A3, is an antibiotic isolated from a number of Streptomyces species, shows antifungal activities. Antimycin A3 is a potent inhibitor of respiration. Antimycin A3 inhibits the electron transfer activity of ubiquinol-cytochrome c oxidoreductase and prevents the growth of human cancer cells. Antimycin A3 also inhibits ATP-citrate lyase with a Ki value of 60.1 µM[1][2][3].

In Vitro

Antimycin A3 induces apoptosis of cancer cells by selectively killing cancer cells that expressed high levels of anti-apoptotic Bcl-2 and Bcl-XL[1].

Molecular Weight

520.58

Formula

C₂₆H₃₆N₂O₉

CAS No.

522-70-3

SMILES

CC(C)CC(O[[email protected]]([[email protected]]1CCCC)[[email protected]](C)OC([[email protected]@H](NC(C2=CC=CC(NC=O)=C2O)=O)[[email protected]@H](C)OC1=O)=O)=O.CCC(C)C(O[[email protected]]([[email protected]]3CCCC)[[email protected]](C)OC([[email protected]@H](NC(C4=CC=CC(NC=O)=C4O)=O)[[email protected]@H](C)OC3=O)=O)=O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Antimycin A3Antimycin A 3Antimycin A-3Mitochondrial MetabolismapoptosisBcl-2Bcl-XLelectrontransferubiquinol-cytochromecoxidoreductaseantifungalInhibitorinhibitorinhibit

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Antimycin A3
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HY-105755
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