1. Protein Tyrosine Kinase/RTK
    Autophagy
  2. VEGFR
    c-Kit
    Src
    RET
    Autophagy
  3. Apatinib free base

Apatinib free base (Synonyms: YN968D1 free base)

Cat. No.: HY-13342A
Handling Instructions

Apatinib free base (YN968D1 free base) is an orally bioavailable tyrosine kinase inhibitor, which selectively targets VEGFR-2 (IC50=1 nM). Apatinib free base (YN968D1 free base) is an anti-angiogenic drug for the treatment of advanced or metastatic gastric cancer. Apatinib free base (YN968D1 free base) potently inhibits Ret, c-Kit and c-Src with IC50s of 13, 429 and 530 nM, respectively. It also inhibits cellular phosphorylation of VEGFR-2, c-kit and PDGFRβ.

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Apatinib free base Chemical Structure

Apatinib free base Chemical Structure

CAS No. : 811803-05-1

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Top Publications Citing Use of Products

    Apatinib free base purchased from MCE. Usage Cited in: BMC Gastroenterol. 2018 Nov 6;18(1):169.

    The cells are treated with Apatinib (100 nM) for 24 h. The invasion cells were stained.

    Apatinib free base purchased from MCE. Usage Cited in: BMC Gastroenterol. 2018 Nov 6;18(1):169.

    The cells are treated with Apatinib (100 nM) for 24 h. The protein expression of Slug, snail and MMP9 in QBC939 cells and TFK-1 cells are measured by western blot.

    Apatinib free base purchased from MCE. Usage Cited in: BMC Gastroenterol. 2018 Nov 6;18(1):169.

    Protein expression of Slug, snail and MMP9 in si-Control and si-KDR cells when treated with 100 ng/ml rhVEGF or 100 ng/ml rhVEGF + 100 nM apatinib for 24 h.

    Apatinib free base purchased from MCE. Usage Cited in: Oncol Lett. 2019 Feb;17(2):1609-1616.

    The protein levels of CHK2 and pCHK2 are determined by western blotting. Lane 1, control group; lane 2, Apatinib group; lane 3, x‑ray group; and lane 4, combination group.

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    Description

    Apatinib free base (YN968D1 free base) is an orally bioavailable tyrosine kinase inhibitor, which selectively targets VEGFR-2 (IC50=1 nM). Apatinib free base (YN968D1 free base) is an anti-angiogenic drug for the treatment of advanced or metastatic gastric cancer. Apatinib free base (YN968D1 free base) potently inhibits Ret, c-Kit and c-Src with IC50s of 13, 429 and 530 nM, respectively. It also inhibits cellular phosphorylation of VEGFR-2, c-kit and PDGFRβ[1][2][3].

    IC50 & Target

    IC50: 1 nM (VEGFR-2), 13 nM (Ret), 429 nM (c-Kit), 530 nM (c-Src)[3]

    Molecular Weight

    397.47

    Formula

    C₂₄H₂₃N₅O

    CAS No.

    811803-05-1

    SMILES

    O=C(C1=CC=CN=C1NCC2=CC=NC=C2)NC3=CC=C(C4(C#N)CCCC4)C=C3

    Shipping

    Room temperature in continental US; may vary elsewhere

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

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