2. Autophagy Apoptosis
  3. Autophagy Apoptosis
  4. Aplyronine A

Aplyronine A is a specific actin-depolymerizing agent. Aplyronine A has antitumor and apoptosis effect. Aplyronine A can be used for the research of cancer and muscle contraction, cell motility and cell division.

For research use only. We do not sell to patients.

Aplyronine A Chemical Structure

Aplyronine A Chemical Structure

CAS No. : 151923-84-1

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Aplyronine A Related Antibodies

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Description

Aplyronine A is a specific actin-depolymerizing agent. Aplyronine A has antitumor and apoptosis effect. Aplyronine A can be used for the research of cancer and muscle contraction, cell motility and cell division[1].

IC50 & Target

IC50: 0.01 nM (HeLa S3 cells)[1].
EC50: 1.3 μM (F-actin)[1]
In Vitro

Aplyronine A (compound 1) has cytotoxicity against HeLa S3 cells with an IC50 value of 0.01 nM[1].
Aplyronine A depolymerizes fibrous actin (F-actin) and inhibits the polymerization of actin with an EC50 value of 1.3 μM in vitro actin-depolymerizing assay[1].
Aplyronine A (0-1 μM, 0-2 h) causes prominent caspase-dependent apoptosis in human epithelial carcinoma HeLa S3 cells[1].
Aplyronine A (100 nM, 24 h) causes malfunction of cell adhesion and dephosphorylation of focal adhesion kinase with apoptosis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Aplyronine A Related Antibodies

Western Blot Analysis[1]

Cell Line: HeLa S3 cells
Concentration: 0-1 μM
Incubation Time: 0-2 h
Result: Induced the dephosphorylation of FAK in HeLa S3 cells.

Apoptosis Analysis[1]

Cell Line: HeLa S3 cells
Concentration: 100 nM
Incubation Time: 24 h
Result: Significantly reduced cellular viabilities in tumor cells and significant activation of caspase 3 in HeLa S3 cells.
In Vivo

Aplyronine A (0.08 mg/kg) exhibits remarkable antitumor activities in vivo against P388 murine leukemia cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

1076.44

Formula

C59H101N3O14
CAS No.
SMILES

O=CN(C)/C=C/[C@@H](C)[C@@H](OC(C)=O)[C@@H](C)[C@H](OC(C(C)N(C)C)=O)CC[C@H](C)[C@H](O)[C@@H]([C@]1([H])C/C=C/[C@@H](C[C@@H](C/C=C([C@H](CC[C@H]([C@H]([C@@H]([C@@H](C/C=C/C=C/C(O1)=O)OC(C(N(C)C)COC)=O)C)O)C)OC)\C)C)OC)C
Structure Classification
Initial Source

Aplysia kurodai
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Aplyronine A Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aplyronine A151923-84-1AutophagyApoptosisspecificactin-depolymerizingantitumorapoptosiscancermuscle contractioncell motilitycell divisionHeLa S3 cellsInhibitorinhibitorinhibit

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