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    Apoptosis
  2. Autophagy
    Apoptosis
  3. Aplyronine A

Aplyronine A 

Cat. No.: HY-N10540
Handling Instructions

Aplyronine A is a specific actin-depolymerizing agent. Aplyronine A has antitumor and apoptosis effect. Aplyronine A can be used for the research of cancer and muscle contraction, cell motility and cell division.

For research use only. We do not sell to patients.

Aplyronine A Chemical Structure

Aplyronine A Chemical Structure

CAS No. : 151923-84-1

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Description

Aplyronine A is a specific actin-depolymerizing agent. Aplyronine A has antitumor and apoptosis effect. Aplyronine A can be used for the research of cancer and muscle contraction, cell motility and cell division[1].

IC50 & Target

IC50: 0.01 nM (HeLa S3 cells)[1].
EC50: 1.3 μM (F-actin)[1]

In Vitro

Aplyronine A (compound 1) has cytotoxicity against HeLa S3 cells with IC50 value of 0.01 nM[1].
Aplyronine A depolymerizes fibrous actin (F-actin) and inhibits the polymerization of actin with an EC50 value of 1.3 μM in vitro actin-depolymerizing assay[1].
Aplyronine A (0-1 μM, 0-2 h) causes prominent caspase-dependent apoptosis in human epithelial carcinoma HeLa S3 cells[1].
Aplyronine A (100 nM, 24 h) causes malfunction of cell adhesion and dephosphorylation of focal adhesion kinase with apoptosis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: HeLa S3 cells
Concentration: 0-1 μM
Incubation Time: 0-2 h
Result: Induced the dephosphorylation of FAK in HeLa S3 cells.

Apoptosis Analysis[1]

Cell Line: HeLa S3 cells
Concentration: 100 nM
Incubation Time: 24 h
Result: Significantly reduced cellular viabilities in tumor cells and significant activation of caspase 3 in HeLa S3 cells.
In Vivo

Aplyronine A (0.08 mg/kg) exhibits remarkable antitumor activities in vivo against P388 murine leukemia cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1076.44

Formula

C59H101N3O14

CAS No.
SMILES

O=CN(C)/C=C/[[email protected]@H](C)[[email protected]@H](OC(C)=O)[[email protected]@H](C)[[email protected]](OC(C(C)N(C)C)=O)CC[[email protected]](C)[[email protected]](O)[[email protected]@H]([[email protected]]1([H])C/C=C/[[email protected]@H](C[[email protected]@H](C/C=C([[email protected]](CC[[email protected]]([[email protected]]([[email protected]@H]([[email protected]@H](C/C=C/C=C/C(O1)=O)OC(C(N(C)C)COC)=O)C)O)C)OC)\C)C)OC)C

Structure Classification
Source

Aplysia kurodai

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Aplyronine A
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