1. Immunology/Inflammation
  2. NO Synthase
  3. AR-C102222 hydrochloride

AR-C102222 hydrochloride is a potent, competitive, orally active and highly selective inducible nitric oxide synthase (iNOS) inhibitor, with an IC50 of 37 nM. AR-C102222 hydrochloride has antinociception and anti-inflammatory activities.

For research use only. We do not sell to patients.

AR-C102222 hydrochloride Chemical Structure

AR-C102222 hydrochloride Chemical Structure

CAS No. : 1781934-50-6

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Solution
10 mM * 1 mL in DMSO USD 308 Ask For Quote & Lead Time
Solid
5 mg USD 280 Ask For Quote & Lead Time
10 mg USD 450 Ask For Quote & Lead Time
25 mg USD 900 Ask For Quote & Lead Time
50 mg USD 1440 Ask For Quote & Lead Time
100 mg USD 2150 Ask For Quote & Lead Time

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Description

AR-C102222 hydrochloride is a potent, competitive, orally active and highly selective inducible nitric oxide synthase (iNOS) inhibitor, with an IC50 of 37 nM[1]. AR-C102222 hydrochloride has antinociception and anti-inflammatory activities[2].

In Vivo

AR-C102222 (3, 10, 30, 100 mg/kg, P.O.) attenuates arachidonic acid-induced ear inflammation and possesses anti-inflammatory activity[2].
AR-C102222 shows good efficacy in a rat adjuvant-induced arthritis model[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Balb/c mice (20-25 g)[2].
Dosage: 3, 10, 30, 100 mg/kg.
Administration: P.O. 55 min before the administration of 0.6% acetic acid (i.p., 1 mL/100 g volume).
Result: Significantly inhibited arachidonic acid-induced ear inflammation following a dose of 100 mg/kg of has a maximal inhibition of approximately 79%.
Molecular Weight

418.83

Formula

C19H17ClF2N6O

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N#CC1=NC=C(C(N2CCC3(NC4=C(C(F)=CC=C4F)C(N)=N3)CC2)=O)C=C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation
References
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AR-C102222 hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
AR-C102222 hydrochloride
Cat. No.:
HY-12122A
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