1. Anti-infection
  2. Fungal
  3. ASP2397

ASP2397 (Synonyms: VL-2397)

Cat. No.: HY-125882
Handling Instructions

ASP2397 (VL-2397), a natural compound, exhibits rapid and potent fungicidal activity against Aspergillus species, at a MIC range of 1 to 4 μg/mL in human serum. ASP2397 (VL-2397) has the potential to treat invasive pulmonary aspergillosis (IPA).

For research use only. We do not sell to patients.

ASP2397 Chemical Structure

ASP2397 Chemical Structure

CAS No. : 2088622-19-7

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Description

ASP2397 (VL-2397), a natural compound, exhibits rapid and potent fungicidal activity against Aspergillus species, at a MIC range of 1 to 4 μg/mL in human serum. ASP2397 (VL-2397) has the potential to treat invasive pulmonary aspergillosis (IPA)[1].

IC50 & Target

MIC: 1-4 μg/mL (Aspergillus species)[1].

In Vivo

ASP2397 (1, 2, 4, or 8 mg/kg, s.c., b.i.d.) significantly improves survival in IPA models in mice[1].

Animal Model: A mouse model of A. fumigatus-induced IPA[1].
Dosage: 1, 2, 4, 8 mg/kg.
Administration: S.C., BID, from day 1 for 3 days.
Result: Significantly improved survival.
Molecular Weight

914.94

Formula

C₄₀H₅₉AlN₁₀O₁₃

CAS No.

2088622-19-7

SMILES

O=C(N[[email protected]@H](CCCN1C(C)=O[Al+3]23(O[N-](CCC4)C(C)=O2)([O-]N(CCC5)C(C)=O3)[O-]1)C(N[[email protected]@H]5C(N[[email protected]@H]4C(N[[email protected]@H](CC(N)=O)C(N[[email protected]]6CC(C)C)=O)=O)=O)=O)[[email protected]](NC6=O)CC7=CC=CC=C7

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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ASP2397
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