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Products are for research use only. Not for human use. We do not sell to patients.

Signaling Pathway

AST 487

HY-15002

(NVP-AST 487)

AST 487

AST 487 Chemical Structure

AST487(NVP-AST487) is a Ret kinase inhibitor/FLT3 inhibitor with IC50 of 0.88 uM for Ret.

Size Price Stock Quantity
5 mg $255 In-stock
10 mg $460 In-stock
50 mg $925 In-stock
100 mg Get quote
200 mg Get quote
Size Price Stock Quantity
5 mg €250 In-stock
10 mg €451 In-stock
50 mg €907 In-stock
100 mg Get quote
200 mg Get quote

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Product name: AST 487
Cat. No.: HY-15002

AST 487 Data Sheet

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    Purity: 99.35%

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    DataSheet

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    MSDS

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    COA

Related Compound Libraries

Biological Activity of AST 487

AST487(NVP-AST487) is a Ret kinase inhibitor/FLT3 inhibitor with IC50 of 0.88 uM for Ret.
IC50 value: 0.88 uM
Target: Ret/FLT3
AST 487 displays high selectivity and potency toward FLT3 as a molecular target, and which could potentially be used to override drug resistance in AML. NVP-AST487 has an IC(50) of 0.88 mumol/L on RET kinase, inhibits RET autophosphorylation and activation of downstream effectors, and potently inhibited the growth of human thyroid cancer cell lines with activating mutations of RET but not of lines without RET mutations. NVP-AST487 induced a dose-dependent growth inhibition of xenografts of NIH3T3 cells expressing oncogenic RET, and of the MTC cell line TT in nude mice. NVP-AST487 inhibited calcitonin gene expression in vitro in TT cells, in part, through decreased gene transcription.

Protocol (Extracted from published papers and Only for reference)

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Chemical Information

M.Wt 529.56 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C₂₆H₃₀F₃N₇O₂
CAS No 630124-46-8
Solvent & Solubility

10 mM in DMSO

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 1.8884 mL 9.4418 mL 18.8836 mL
5 mM 0.3777 mL 1.8884 mL 3.7767 mL
10 mM 0.1888 mL 0.9442 mL 1.8884 mL

References on AST 487

Inhibitor Kit

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