1. Anti-infection
  2. Bacterial HCV SARS-CoV
  3. Astodrimer

Astodrimer (SPL7013 free base) is a large (3-4 nm, ~ 16.5 kDa), negatively charged, highly-branched dendrimer, is a potent virucidal agent. Astodrimer shows antiviral and virucidal activity against a broad spectrum of viruses, including SARS-CoV-2, HIV-1, HSV-1, HSV-2, HPV. Astodrimer also has antibacterial properties.

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Astodrimer Chemical Structure

Astodrimer Chemical Structure

CAS No. : 1379746-42-5

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Description

Astodrimer (SPL7013 free base) is a large (3-4 nm, ~ 16.5 kDa), negatively charged, highly-branched dendrimer, is a potent virucidal agent. Astodrimer shows antiviral and virucidal activity against a broad spectrum of viruses, including SARS-CoV-2, HIV-1, HSV-1, HSV-2, HPV. Astodrimer also has antibacterial properties[1][2][3].

In Vitro

Astodrimer (0-10 mg/mL; 4 days) inhibits SARS-CoV-2 (hCoV-19/Australia/VIC01/2020) replication against SARS-CoV-2 (hCoV-19/Australia/VIC01/2020) infection of Vero E6 cells[1].
Astodrimer inhibits the 2019-nCoV/USA-WA1/2020 strain with EC50 values of 0.019–0.032 mg/mL and 0.030–0.037 mg/mL for infectious virus in Vero E6 cell and Calu-3 cells, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: Vero E6 cells
Concentration: 0-10 mg/mL(1 h prior to infection, or 1 h post-infection with SARS-CoV-2)
Incubation Time: 4 days
Result: Inhibited viral replication when added either 1 h prior to infection, or 1 h post-infection with SARS-CoV-2 in a dose dependent manner.
In Vivo

Astodrimer (3%, 8 times daily for 4 days then 4 times daily for 6 days) is non-toxic to rabbit eyes and has anti-adenoviral activity in NZW rabbits[2].
Astodrimer (1%, intranasal administration; once daily for 5 days) reduces the severity of SARS-CoV-2 replication and pathogenesis in the highly susceptible K18-hACE2 mouse model[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Two- to three-pound female NZW rabbits (both eyes with HAdV5 following corneal scarification)[2].
Dosage: 3% SPL7013
Administration: 8 times daily for 4 days then 4 times daily for 6 days
Result: Inactivated the virus, and the resulting reduction in the exposure to the virus in vivo limits SARS-CoV-2 infection, resulting in significantly lower viral loads and infectious virus in the lung, trachea, brain and liver of K18-hACE2 mic, and significantly lower pro-inflammatory cytokine production.
Animal Model: Six-to-eight-week-old K18-hACE2 mice[3]
Dosage: 1% astodrimer sodium nasal spray
Administration: Intranasal administration; 25 µL/nostril; once daily on Days 1-6.
Result: Significantly reduced the severity of SARS-CoV-2 replication and pathogenesis in the highly susceptible K18-hACE2 mouse model.
CAS No.
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Purity & Documentation
References
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Astodrimer Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Astodrimer
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HY-P3626
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