1. Metabolic Enzyme/Protease
  2. Aldose Reductase
  3. AT-007

AT-007 

Cat. No.: HY-129586 Purity: 99.33%
Handling Instructions

AT-007 is an orally active central nervous system (CNS) penetrant Aldose Reductase inhibitor for treatment of Galactosemia with an IC50 value of 100 pM. AT-007 reduces toxic galactitol levels and prevents disease complications in GALT deficiency rats.

For research use only. We do not sell to patients.

AT-007 Chemical Structure

AT-007 Chemical Structure

CAS No. : 2170729-29-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 328 In-stock
Estimated Time of Arrival: December 31
1 mg USD 120 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
25 mg USD 990 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

AT-007 is an orally active central nervous system (CNS) penetrant Aldose Reductase inhibitor for treatment of Galactosemia with an IC50 value of 100 pM. AT-007 reduces toxic galactitol levels and prevents disease complications in GALT deficiency rats[1][2].

IC50 & Target

IC50: 100 pM (Aldose Reductase)[2]

In Vivo

AT-007 significantly reduces galactitol levels in GALT null rats in all traget tissues ( liver, brain and plasma), and does not increase galactose or Gal-1P levels[2].

Molecular Weight

425.40

Formula

C₁₇H₁₀F₃N₃O₃S₂

CAS No.

2170729-29-8

SMILES

O=C(O)CC(C1=CSC=C12)=NN(CC3=NC4=CC(C(F)(F)F)=CC=C4S3)C2=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 35.71 mg/mL (83.94 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3507 mL 11.7536 mL 23.5073 mL
5 mM 0.4701 mL 2.3507 mL 4.7015 mL
10 mM 0.2351 mL 1.1754 mL 2.3507 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.25 mg/mL (5.29 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.25 mg/mL (5.29 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

AT-007AT007AT 007Aldose ReductaseInhibitorinhibitorinhibit

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Product name:
AT-007
Cat. No.:
HY-129586
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