ATP-¹³C₁₀,¹⁵N₅ disodium  (Synonyms: Adenosine 5'-triphosphate-¹³C₁₀,¹⁵N₅ disodium)

ATP-¹³C₁₀,¹⁵N₅ (disodium) is a ¹³C-labeled and ¹⁵N-labeled ATP (HY-B2176). ATP is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation[1][2][3][4].

ATP-13C10,15N5 (Adenosine 5'-triphosphate-13C10,15N5; 5 mM; 1 hour) disodium co-treatment with LPS (1 μg/mL) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs^[3].
ATP-13C10,15N5 (2 mM; 0.5-24 hours) disodium induces secretion of IL-1β, KC and MIP-2 from BMDMs in a caspase-1 activation-dependent manner^[4].
ATP-13C10,15N5 disodium promotes neutrophil chemotaxis in vitro^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ATP-13C10,15N5 (Adenosine 5'-triphosphate-13C10,15N5; 50 mg/kg; i.p.) disodium protects mice against bacterial infection in vivo^[4].
ATP-13C10,15N5 disodium induces the secretion of IL-1β, KC and MIP-2 and neutrophils recruitment in vivo^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

566.04

¹³C₁₀H₁₄¹⁵N₅Na₂O₁₃P₃

Liquid

Colorless to light yellow

O=P(O)(O[Na])OP(OP(O[13CH2][13C@H]1O[13C@@H]([15N]2[13C]3=[15N][13CH]=[15N][13C]([15NH2])=[13C]3[15N]=[13CH]2)[13C@H](O)[13C@@H]1O)(O)=O)(O[Na])=O

Room temperature in continental US; may vary elsewhere.

Solution, -20°C, 2 years

• [1]. Swennen EL, et al. Immunoregulatory effects of adenosine 5'-triphosphate on cytokine release from stimulated whole blood. Eur J Immunol. 2005 Mar;35(3):852-8.  [Content Brief]

  [2]. M J L Bours, et al. Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol Ther. 2006 Nov;112(2):358-404.  [Content Brief]

  [3]. Shuo Xu, et al. Doxycycline inhibits NAcht Leucine-rich repeat Protein 3 inflammasome activation and interleukin-1β production induced by Porphyromonas gingivalis-lipopolysaccharide and adenosine triphosphate in human gingival fibroblasts. Arch Oral Biol. 2019 Nov;107:104514.  [Content Brief]

  [4]. Yang Xiang, et al. Adenosine-5'-Triphosphate (ATP) Protects Mice against Bacterial Infection by Activation of the NLRP3 Inflammasome. PLoS One. 2013; 8(5): e63759.  [Content Brief]