2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Apoptosis
  3. COX Reactive Oxygen Species TrxR Apoptosis
  4. [Au(L4)(CyJohnPhos)]SbF6

[Au(L4)(CyJohnPhos)]SbF6 is a gold containing complex. [Au(L4)(CyJohnPhos)]SbF6 inhibits cyclooxygenase-1/2 (COX-1/2), inhibits the proliferation (IC50 is 0.98 μM) and induces apoptosis in colon cancer cell Caco2-/TC7. [Au(L4)(CyJohnPhos)]SbF6 is also an inhibitor for thioredoxin reductase (TrxR), thereby exhibits antioxidant activity by modulating ROS levels.

For research use only. We do not sell to patients.

[Au(L4)(CyJohnPhos)]SbF6 Chemical Structure

[Au(L4)(CyJohnPhos)]SbF6 Chemical Structure

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

[Au(L4)(CyJohnPhos)]SbF6 Related Antibodies

Top Publications Citing Use of Products

View All COX Isoform Specific Products:

View All Isoforms
COX COX-1 COX-2 COX-3

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

[Au(L4)(CyJohnPhos)]SbF6 is a gold containing complex. [Au(L4)(CyJohnPhos)]SbF6 inhibits cyclooxygenase-1/2 (COX-1/2), inhibits the proliferation (IC50 is 0.98 μM) and induces apoptosis in colon cancer cell Caco2-/TC7. [Au(L4)(CyJohnPhos)]SbF6 is also an inhibitor for thioredoxin reductase (TrxR), thereby exhibits antioxidant activity by modulating ROS levels[1].

Molecular Weight

1158.68

Formula

C44H56AuF6NO4PSSb
SMILES

COC1=CC2=C(C=C1)C=C([C@H](C)C(NC(CC[S]([Au+][P](C3CCCCC3)(C4CCCCC4)C5=CC=CC=C5C6=CC=CC=C6)C)C(OC)=O)=O)C=C2.F[Sb](F)(F)(F)F.[F-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

[Au(L4)(CyJohnPhos)]SbF6 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

[Au(L4)(CyJohnPhos)]SbF6COXReactive Oxygen SpeciesTrxRApoptosisCyclooxygenaseThioredoxin Reductasecolon cancer,Caco2-/TC7antioxidantInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
[Au(L4)(CyJohnPhos)]SbF6
Cat. No.:
HY-169286
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.