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Aurothioglucose (Synonyms: Gold thioglucose)

Cat. No.: HY-A0068
Handling Instructions

Aurothioglucose (Gold thioglucose) is a well known active-site inhibitor of TrxR1, inhibited TrxR1 activity in HeLa cell cytosol but had no effect on the viability of the cells.

For research use only. We do not sell to patients.

Aurothioglucose Chemical Structure

Aurothioglucose Chemical Structure

CAS No. : 12192-57-3

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 172 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 172 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 156 In-stock
Estimated Time of Arrival: December 31
10 mg USD 252 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Aurothioglucose

  • Biological Activity

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Description

Aurothioglucose (Gold thioglucose) is a well known active-site inhibitor of TrxR1, inhibited TrxR1 activity in HeLa cell cytosol but had no effect on the viability of the cells. IC50 value: Target: TrxR1 in vitro: Trx1 redox state and ROS generation were measured in cells exposed to the TrxR1 inhibitors aurothioglucose (ATG) and monomethylarsonous acid (MMA(III)) and in cells depleted of TrxR1 activity by siRNA knock down [1]. in vivo: Adult mice received a single intratracheal dose of 0.375 μg/g lipopolysaccharide (LPS) 12 h before a single intraperitoneal injection of 25 mg/kg ATG. Control mice received intratracheal and/or intraperitoneal saline. ATG treatment significantly attenuated lung injury, increased lung GCLM expression and GSH levels, and decreased mortality. GSH depletion completely prevented the protective effects of ATG in LPS/hyperoxia-exposed mice [2].

Molecular Weight

392.18

Formula

C₆H₁₁AuO₅S

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (318.73 mM; Need ultrasonic)

DMSO : 6 mg/mL (15.30 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5498 mL 12.7492 mL 25.4985 mL
5 mM 0.5100 mL 2.5498 mL 5.0997 mL
10 mM 0.2550 mL 1.2749 mL 2.5498 mL
*Please refer to the solubility information to select the appropriate solvent.
References

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Product Name:
Aurothioglucose
Cat. No.:
HY-A0068
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