1. Anti-infection
  2. Reverse Transcriptase
    HIV
    HBV
    HCV
  3. Azvudine hydrochloride

Azvudine hydrochloride (Synonyms: RO-0622 hydrochloride; FNC hydrochloride)

Cat. No.: HY-19314A Purity: >97.0%
Handling Instructions

Azvudine (RO-0622) hydrochloride is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV. Azvudine hydrochloride exerts highly potent inhibition on HIV-1 (EC50s ranging from 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM). Azvudine hydrochloride inhibits NRTI-resistant viral strains.

For research use only. We do not sell to patients.

Azvudine hydrochloride Chemical Structure

Azvudine hydrochloride Chemical Structure

CAS No. : 1333126-31-0

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10 mM * 1 mL in DMSO USD 330 In-stock
Estimated Time of Arrival: December 31
5 mg USD 300 In-stock
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10 mg USD 480 In-stock
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50 mg USD 1350 In-stock
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100 mg USD 2050 In-stock
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Description

Azvudine (RO-0622) hydrochloride is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV. Azvudine hydrochloride exerts highly potent inhibition on HIV-1 (EC50s ranging from 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM). Azvudine hydrochloride inhibits NRTI-resistant viral strains[1].

IC50 & Target[1]

HIV-1

0.03-6.92 nM (EC50)

HIV-2

0.018-0.02 nM (EC50)

In Vitro

Azvudine (RO-0622) hydrochloride displays strong inhibition on wild-type HIV-1IIIB and HIV-1RF with an EC50 ranging from 30 to 110 pM. The EC50 values of Azvudine hydrochloride against HIV-1KM018, HIV-1TC-1 and HIV-1WAN T69N are 6.92, 0.34 and 0.45 nM, respectively. Azvudine is sensitive to NRTIs-resistant strain HIV-174V, PIs-resistant strains HIV-1L10R/M46I/L63P/V82T/I84V and HIV-1RF V82F/184V, and FIs-resistant strain pNL4-3gp41 (36G) V38A/N42T. The EC50 values of Azvudine hydrochloride against these resistant strains are 0.11, 0.14, 0.37 and 0.36 nM respectively[1].

Molecular Weight

322.68

Formula

C₉H₁₂ClFN₆O₄

CAS No.

1333126-31-0

SMILES

NC(C=CN1[[email protected]@H]2O[[email protected]@](N=[N+]=[N-])([[email protected]]([[email protected]@H]2F)O)CO)=NC1=O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (387.38 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0990 mL 15.4952 mL 30.9905 mL
5 mM 0.6198 mL 3.0990 mL 6.1981 mL
10 mM 0.3099 mL 1.5495 mL 3.0990 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

AzvudineRO-0622FNCRO0622RO 0622Reverse TranscriptaseHIVHBVHCVHuman immunodeficiency virusHepatitis B virusHepatitis C virusNRTIresistantmutationanalogueInhibitorinhibitorinhibit

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Product Name:
Azvudine hydrochloride
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