1. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  2. Histamine Receptor
  3. Bavisant dihydrochloride hydrate

Bavisant dihydrochloride hydrate  (Synonyms: JNJ31001074AAC; JNJ31001074 dihydrochloride hydrate)

Cat. No.: HY-14880B Purity: 99.26%
COA Handling Instructions

Bavisant dihydrochloride hydrate (JNJ31001074AAC) is an orally active, potent, brain-penetrating and highly selective antagonist of the histamine H3 receptor. Bavisant dihydrochloride hydrate can be used for attention-deficit hyperactivity disorder (ADHD) research.

For research use only. We do not sell to patients.

Bavisant dihydrochloride hydrate Chemical Structure

Bavisant dihydrochloride hydrate Chemical Structure

CAS No. : 1103522-80-0

Size Price Stock Quantity
5 mg USD 180 In-stock
10 mg USD 280 In-stock
25 mg USD 480 In-stock
50 mg USD 680 In-stock
100 mg   Get quote  
200 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Other Forms of Bavisant dihydrochloride hydrate:

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  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

Bavisant dihydrochloride hydrate (JNJ31001074AAC) is an orally active, potent, brain-penetrating and highly selective antagonist of the histamine H3 receptor. Bavisant dihydrochloride hydrate can be used for attention-deficit hyperactivity disorder (ADHD) research[1][2][3].

IC50 & Target

H3 receptor

 

In Vivo

Bavisant dihydrochloride hydrate increases acetylcholine levels in rat frontal cortex[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

420.37

Formula

C19H31Cl2N3O3

CAS No.
Appearance

Solid

Color

White to pink

SMILES

O=C(N1CCN(C2CC2)CC1)C(C=C3)=CC=C3CN4CCOCC4.[H]Cl.[H]Cl.O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL (118.94 mM)

DMSO : ≥ 1 mg/mL (2.38 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3789 mL 11.8943 mL 23.7886 mL
5 mM 0.4758 mL 2.3789 mL 4.7577 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (118.94 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.26%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 2.3789 mL 11.8943 mL 23.7886 mL 59.4714 mL
H2O 5 mM 0.4758 mL 2.3789 mL 4.7577 mL 11.8943 mL
10 mM 0.2379 mL 1.1894 mL 2.3789 mL 5.9471 mL
15 mM 0.1586 mL 0.7930 mL 1.5859 mL 3.9648 mL
20 mM 0.1189 mL 0.5947 mL 1.1894 mL 2.9736 mL
25 mM 0.0952 mL 0.4758 mL 0.9515 mL 2.3789 mL
30 mM 0.0793 mL 0.3965 mL 0.7930 mL 1.9824 mL
40 mM 0.0595 mL 0.2974 mL 0.5947 mL 1.4868 mL
50 mM 0.0476 mL 0.2379 mL 0.4758 mL 1.1894 mL
60 mM 0.0396 mL 0.1982 mL 0.3965 mL 0.9912 mL
80 mM 0.0297 mL 0.1487 mL 0.2974 mL 0.7434 mL
100 mM 0.0238 mL 0.1189 mL 0.2379 mL 0.5947 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Bavisant dihydrochloride hydrate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Bavisant dihydrochloride hydrate
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