1. GPCR/G Protein
    Immunology/Inflammation
  2. Histamine Receptor
  3. Bilastine

Bilastine 

Cat. No.: HY-14447 Purity: 99.95%
Handling Instructions

Bilastine is a selective histamine H1 receptor antagonist used for treatment of allergic rhinoconjunctivitis and urticaria.

For research use only. We do not sell to patients.

Bilastine Chemical Structure

Bilastine Chemical Structure

CAS No. : 202189-78-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 132 In-stock
Estimated Time of Arrival: December 31
10 mg USD 120 In-stock
Estimated Time of Arrival: December 31
50 mg USD 480 In-stock
Estimated Time of Arrival: December 31
100 mg USD 840 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

Bilastine is a selective histamine H1 receptor antagonist used for treatment of allergic rhinoconjunctivitis and urticaria. Target: Histamine H1 Receptor Bilastine binds to histamine H1-receptors as indicated by its displacement of [3H]-pyrilamine from H1-receptors expressed in guinea-pig cerebellum and human embryonic kidney (HEK) cell lines. The studies conducted on guinea-pig smooth muscle demonstrated the capability of bilastine to antagonise H1-receptors. Bilastine is selective for histamine H1-receptors as shown in receptor-binding screening conducted to determine the binding capacity of bilastine to 30 different receptors [1]. Bilastine distribution has an apparent volume of distribution of 1.29 L/kg, and has an elimination half-life of 14.5 h and plasma protein binding of 84-90% [2].

Clinical Trial
Molecular Weight

463.61

Formula

C₂₈H₃₇N₃O₃

CAS No.

202189-78-4

SMILES

CC(C)(C1=CC=C(CCN2CCC(C3=NC4=CC=CC=C4N3CCOCC)CC2)C=C1)C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 49.3 mg/mL (106.34 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1570 mL 10.7849 mL 21.5699 mL
5 mM 0.4314 mL 2.1570 mL 4.3140 mL
10 mM 0.2157 mL 1.0785 mL 2.1570 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.95%

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Product Name:
Bilastine
Cat. No.:
HY-14447
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