Zinc finger protein 827

Definition:

As part of a ribonucleoprotein complex composed at least of HNRNPK, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation. Could also recruit the nucleosome remodeling and histone deacetylase/NuRD complex to telomeric regions of chromosomes to regulate chromatin remodeling as part of telomere maintenance.

References:

[1]. Anne Kruse Hollensen, et al. circZNF827 nucleates a transcription inhibitory complex to balance neuronal differentiation. Elife. 2020 Nov 11;9:e58478. [Content Brief]

[2]. Dimitri Conomos, et al. NuRD-ZNF827 recruitment to telomeres creates a molecular scaffold for homologous recombination. Nat Struct Mol Biol. 2014 Sep;21(9):760-70. [Content Brief]

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