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Products are for research use only. Not for human use. We do not sell to patients.

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BIX-01294

HY-10587

(BIX 01294; BIX01294)

BIX-01294

BIX-01294 Chemical Structure

BIX01294 is an inhibitor of G9a histone methyltransferase with IC50 of 2.7 μM.

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Free sample   Apply now  
10 mM * 1 mL in DMSO $136 In-stock
10 mg $124 In-stock
50 mg $414 In-stock
100 mg Get quote
200 mg Get quote
Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO €133 In-stock
10 mg €122 In-stock
50 mg €406 In-stock
100 mg Get quote
200 mg Get quote

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Product name: BIX-01294
Cat. No.: HY-10587

BIX-01294 Data Sheet

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    Purity: 99.22%

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Biological Activity of BIX-01294

BIX01294 is an inhibitor of G9a histone methyltransferase with IC50 of 2.7 μM.
IC50 Value: 2.7 μM
Target: HMTase
BIX-01294, a diazepin-quinazolinamine derivative, is a selective inhibitor of G9a histone methyl transferase (G9a HMTase) that impairs G9a HMTase and generation of H3K9me2 in vitro. In its inhibition of the histone lysine methyltransferases, BIX-01294 does not compete with cofactor S-adenosyl-methionine. G9a HMTase regulates gene expression including one of the pluripotency genes Oct4. It is reported that BIX-01294 enhances reprogramming efficiency of neural progenitor cells to the same levels as when four transcription factors (Oct4, Klf4, Sox2 and c-Myc) were introduced to somatic cells for generation of induced pluripotent stem cells. BIX-01294 and valproic acid, a histone deacetylase (HDAC) inhibitor, may replace the requirement for ectopic OCT4 (POU5F1) and cMyc respectively in pluripotent stem cell induction (iPS) recipes.

Protocol (Extracted from published papers and Only for reference)

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Chemical Information

M.Wt 490.64 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C28H38N6O2
CAS No 935693-62-2
Solvent & Solubility

DMSO 98 mg/mL; Water 98 mg/mL

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 2.0382 mL 10.1908 mL 20.3815 mL
5 mM 0.4076 mL 2.0382 mL 4.0763 mL
10 mM 0.2038 mL 1.0191 mL 2.0382 mL

References on BIX-01294

Inhibitor Kit

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