1. Cell Cycle/DNA Damage
  2. G-quadruplex
  3. BMVC-8C3O

BMVC-8C3O 

Cat. No.: HY-133234 Purity: 99.01%
Handling Instructions

BMVC-8C3O is a DNA G-quadruplexe (G4) ligand which can induce topological conversion of non-parallel to parallel forms in human telomeric DNA G4s.

For research use only. We do not sell to patients.

BMVC-8C3O Chemical Structure

BMVC-8C3O Chemical Structure

CAS No. : 1301708-12-2

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 780 In-stock
Estimated Time of Arrival: December 31
5 mg USD 400 In-stock
Estimated Time of Arrival: December 31
10 mg USD 680 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1750 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2350 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

BMVC-8C3O is a DNA G-quadruplexe (G4) ligand which can induce topological conversion of non-parallel to parallel forms in human telomeric DNA G4s[1].

In Vitro

BMVC-8C3O induces topological conversion of Tel23 from a hybrid-I G4 to a parallel G4 in K+solution[1].
BMVC-8C3O binding can induce topological changes of different non-parallel human telomeric G4s into the same parallel topology[1].

Molecular Weight

1042.61

Formula

C₄₂H₅₃I₃N₄O₃

CAS No.

1301708-12-2

SMILES

C[N+]1(CCOCCOCCOCCN2C3=C(C4=C2C=CC(/C=C/C5=CC=[N+](C)C=C5)=C4)C=C(/C=C/C6=CC=[N+](C)C=C6)C=C3)CCCCC1.[I-].[I-].[I-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (59.95 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9591 mL 4.7957 mL 9.5913 mL
5 mM 0.1918 mL 0.9591 mL 1.9183 mL
10 mM 0.0959 mL 0.4796 mL 0.9591 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (1.99 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (1.99 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

BMVC-8C3OG-quadruplexG4-ligandtelomeric,topologicalconversionG-quadruplexeInhibitorinhibitorinhibit

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Product Name:
BMVC-8C3O
Cat. No.:
HY-133234
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