2. Epigenetics
  3. Epigenetic Reader Domain
  4. BRD4 Inhibitor-26

BRD4 Inhibitor-26 is a bromodomain protein 4 (BRD4) inhibitor/nitric oxide-donator. BRD4 Inhibitor-26 inhibits BRD4 (BD1) and BRD4 (BD2) with IC50 values of 0.82 μM and 1.94 μM, respectively. BRD4 Inhibitor-26 can be used for the research of ovarian cancer.

For research use only. We do not sell to patients.

BRD4 Inhibitor-26 Chemical Structure

BRD4 Inhibitor-26 Chemical Structure

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BRD4 Inhibitor-26 Related Antibodies

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Description

BRD4 Inhibitor-26 is a bromodomain protein 4 (BRD4) inhibitor/nitric oxide-donator. BRD4 Inhibitor-26 inhibits BRD4 (BD1) and BRD4 (BD2) with IC50 values of 0.82 μM and 1.94 μM, respectively. BRD4 Inhibitor-26 can be used for the research of ovarian cancer[1].

IC50 & Target

IC50: 0.82 μM (BRD4 (BD1)); 1.94 μM (BRD4 (BD2)); 1.38-8.47 μM (OC cells)[1].
Kd: 0.419 μM (BRD4 (BD1)); 0.686 μM (BRD4 (BD2))[1]
In Vitro

BRD4 Inhibitor-26 (Compound 11a) has inhibitory activity for BRD4 (BD1) and BRD4 (BD2) with IC50 values of 0.82 μM and 1.94 μM, respectively[1].
BRD4 Inhibitor-26 has inhibitory activity for BRD4 (BD1) and BRD4 (BD2) with Kd values of 0.419 μM and 0.686 μM, respectively[1].
BRD4 Inhibitor-26 has inhibitory activity for OC cells with IC50 values range from 1.38-8.47 μM[1].
BRD4 Inhibitor-26 (0, 1.0 and 2.0 μM; 24 h) significantly decreased the expression of BRD4 and c-Myc, as well as induced cellular apoptosis and autophagic cell death[1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BRD4 Inhibitor-26 Related Antibodies

Apoptosis Analysis[1]

Cell Line: SKOV-3 cells
Concentration: 0, 1.0 and 2.0 μM
Incubation Time: 24 h
Result: Increased the percentages of total apoptotic cells and showed dose-dependent in early apoptotic cells.

Western Blot Analysis[1]

Cell Line: SKOV-3 cells
Concentration: 0, 1.0 and 2.0 μM
Incubation Time: 24 h
Result: Up-regulated the classical apoptosis-related proteins Cytochrome c, down-regulated the anti-apoptosis protein Bcl-2 and Cleaved-caspase 3 and also up-regulated the autophagy-related proteins LC3II/I, p62/SQSTM1 and Beclin1.

Immunofluorescence[1]

Cell Line: SKOV-3 cells
Concentration: 2.0 μM
Incubation Time: 24 h
Result: [1]
In Vivo

BRD4 Inhibitor-26 (i.p.; 30 mg/kg) has anti-tumor activity and induces cellular apoptosis in vivo[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Balb/c nude mice[1]
Dosage: 30 mg/kg
Administration: Intraperitoneal administration
Result: Suppressed the ovarian cancer cells proliferation via BRD4 inhibition and activated apoptosis.
Molecular Weight

573.62

Formula

C29H27N5O6S
SMILES

[O-][N+]1=C(C(C2=CC=CC=C2)=NO1)COC(COC3=C(C=C(C=C3C)C4=NC5=C(C6=C(S5)CN(CC6)C)C(N4)=O)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BRD4 Inhibitor-26 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BRD4 Inhibitor-26Epigenetic Reader Domainbromodomain protein 4 (BRD4)nitric oxide-donatorovarian cancerInhibitorinhibitorinhibit

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