1. GPCR/G Protein
    Neuronal Signaling
  2. Opioid Receptor
  3. BTRX-335140

BTRX-335140 (Synonyms: CYM-53093)

Cat. No.: HY-124754
Handling Instructions

BTRX-335140 (CYM-53093) is a potent and selective, orally active κ opioid receptor (KOR) antagonist, has antagonist activity for κOR, μOR and δOR with IC50 values of 0.8 nM, 110 nM, and 6500 nM, respectively. BTRX-335140 endows with favorable in vitro ADMET and in vivo pharmacokinetic profiles and medication-like duration of action in rats. BTRX-335140 can distribute well into the CNS. ADMET (absorption, distribution, metabolism, excretion, and toxicity) .

For research use only. We do not sell to patients.

BTRX-335140 Chemical Structure

BTRX-335140 Chemical Structure

CAS No. : 2244614-14-8

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Description

BTRX-335140 (CYM-53093) is a potent and selective, orally active κ opioid receptor (KOR) antagonist, has antagonist activity for κOR, μOR and δOR with IC50 values of 0.8 nM, 110 nM, and 6500 nM, respectively. BTRX-335140 endows with favorable in vitro ADMET and in vivo pharmacokinetic profiles and medication-like duration of action in rats. BTRX-335140 can distribute well into the CNS. ADMET (absorption, distribution, metabolism, excretion, and toxicity) [1].

IC50 & Target

IC50: 0.8 nM (κOR); 110 nM (μOR); 6500 nM (δOR)[1]

Molecular Weight

453.55

Formula

C₂₅H₃₂FN₅O₂

CAS No.

2244614-14-8

SMILES

CC1=NOC(C2=C(C)C3=CC(CC)=CC(F)=C3N=C2N4CCC(NC5CCOCC5)CC4)=N1

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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