Successful, we will reply to you quickly.OK
Please select the quantity.OK
Your message is being sent, please wait.Close
Send mail failed, please send again!Close
Products are for research use only. Not for human use. We do not sell to patients.
Capadenoson Chemical Structure
|Product name: Capadenoson|
|Cat. No.: HY-14917|
Capadenoson (BAY 68-4986) is a new adenosine A1 receptor agonist.
Target: adenosine A1 receptor
Studies showed that long-term therapy with Capadenoson improves phosphorylation and total protein level of PGC-1α in LV myocardium of HF dogs. Clinical trial found that in patients with stable angina Capadenoson lowers exercise HR at comparable maximum workload, which is associated with improved total exercise time and prolongation of time to ischaemia.
|M.Wt||520.03||Storage||Please store the product under the recommended conditions in the Certificate of Analysis.|
|Solvent & Solubility||
10 mM in DMSO
|1 mg||5 mg||10 mg|
|1 mM||1.9230 mL||9.6148 mL||19.2297 mL|
|5 mM||0.3846 mL||1.9230 mL||3.8459 mL|
|10 mM||0.1923 mL||0.9615 mL||1.9230 mL|
|Product Name||Sponsor Only||Condition||Start Date||End Date||Phase||Last Change Date|
|Capadenoson||Bayer AG||Angina||31-MAR-08||01-NOV-08||Phase 2||12-SEP-13|
|Bayer AG||Atrial fibrillation||23-JAN-08||31-DEC-08||Phase 2||12-JUN-13|
. Ramesh C. Gupta, et al. Long-term therapy with the partial adenosine A1-receptor agnosit capadenoson, improves peroxisome proliferator-activated receptor coactivator-1α phosphorylation and protein expression in left ventricular myocardium of dogs with chronic heart failure. J Am Coll Cardiol. 2013;61(10_S).
2-Cl-IB-MECA is a selective A3 adenosine receptor agonist (Ki = 0.33 nM). Displays 2500- and 1400-fold selectivity over A1 and A2A receptors respectively.
A2AR-agonist-1 is a potent A2AR and ENT1 agonist with Ki of 4.39 and 3.47 for A2AR and ENT1.
AB-MECA is a high affinity A3 adenosine receptor agonist, has high affinity for recombinant A1 and A3 receptors.
Dyphylline acts as an adenosine receptor antagonist and phosphodiesterase inhibitor, which is used in the treatment of respiratory disorders.
GR79236 is a highly potent and selective adenosine A1 receptor agonist (Ki = 3.1 nM) that has analgesic and anti-inflammatory actions in humans and animals.
IB-MECA is an agonist of the adenosine A3 receptor with EC50 values of 0.11 (mu)M.
Istradefylline(KW6002) is a very potent, selective and orally active adenosine A2A receptor antagonist(Ki=2.2 nM) in experimental models of Parkinson(acute)s disease.
LUF6000 is an allosteric modulator of the human A3 adenosine receptor (AR).
N-[(4-Aminophenyl)methyl]adenosine is a adenosine receptor inhibitor, with Ki of 29 nM for Rat ecto-5′-Nucleotidase.
N6-Cyclohexyladenosine is a selective A1 receptor agonist (EC50 = 8.2 nM).
Other Countries & RegionsSee Worldwide Distributors