Carbamazepine 10,11-epoxide-¹³C,d₂ 

Carbamazepine 10,11-epoxide-¹³C,d₂ is the deuterium labeled Carbamazepine 10,11-epoxide-C13. Carbamazepine 10,11-epoxide-C13 is a ¹³C-labled Carbamazepine 10,11-epoxide. Carbamazepine 10,11-epoxide is an orally active metabolite of Carbamazepine (HY-B0246). Carbamazepine has anticonvulsant effect. Carbamazepine can be used for the research of seizures[1][2].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

255.27

C₁₄¹³CH₁₀D₂N₂O₂

1189497-48-0

N[13C](N1C2=CC=CC=C2C3([2H])C(C4=CC=CC=C41)([2H])O3)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. T Tomson, et al. Single-dose kinetics and metabolism of carbamazepine-10,11-epoxide. Clin Pharmacol Ther. 1983 Jan;33(1):58-65.  [Content Brief]