1. Immunology/Inflammation
  2. NO Synthase
  3. Carboxyebselen

Carboxyebselen (Synonyms: HOOC-Ebs)

Cat. No.: HY-139448
Handling Instructions

Carboxyebselen (HOOC-Ebs) is a potent and selective inhibitor of endothelial nitric oxide synthase (eNOS).

For research use only. We do not sell to patients.

Carboxyebselen Chemical Structure

Carboxyebselen Chemical Structure

CAS No. : 153871-75-1

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Carboxyebselen (HOOC-Ebs) is a potent and selective inhibitor of endothelial nitric oxide synthase (eNOS)[1].

In Vivo

Carboxyebselen (HOOC-Ebs), a derivative of Ebselen (Ebs) inhibits NOS present in enzymatic preparations from bovine endothelium, porcine cerebella, and murine spleen, however, it is both more potent and more selective for the constitutive endothelial NOS than Ebs. Unlike Ebs, HOOC-Ebs (0.1-30 microM) causes a concentration-dependent endothelium-independent relaxations of rings of rabbit aorta[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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