CD147 degrader 1 

CD147 degrader 1 is a PROTAC targets CD147 with an DC₅₀ value of 6.72 µM. CD147 degrader 1 inhibits cell proliferation, migration and invasion. CD147 degrader 1 decreases the expression of CD147, MMP9, and p-STAT3 protein. CD147 degrader 1 shows anti-cancer acyivity^[1].

CD147 degrader 1 (compound 6a) (2.5, 10 µM; 0, 24, 48 h) inhibits cell migration and invasion in Sk-Mel-28 cells^[1].
CD147 degrader 1 (0, 2.5, 5, 10 µM) decreases the expression of CD147, MMP9, p-STAT3 protein in a dose-dependent manner^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CD147 degrader 1 (20 mg/kg; i.p.; every two days for 17 days) shows anti-cancer activity in mice^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

730.76

C₃₈H₄₂N₄O₁₁

2416740-37-7

O=C(C1=CC=CC(NCCNC(/C(C)=C/C=C/[[email protected]](OC2=O)(C)[[email protected]@]3([H])[[email protected]](CCC(C(OC)=O)=CC4)(OC(C)=O)[[email protected]@]42CC3)=O)=C15)N(C6CCC(NC6=O)=O)C5=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Zhou Z, et al. Targeted degradation of CD147 proteins in melanoma. Bioorg Chem. 2020 Dec;105:104453.  [Content Brief]