1. Cell Cycle/DNA Damage
  2. CDK
  3. Cdc7-IN-6

Cdc7-IN-6 

Cat. No.: HY-130518
Handling Instructions

Cdc7-IN-6 (compound I-D) is a potent Cdc7 kinase inhibitor (IC50=4 nM), extracted from patent WO2019165473A1, compound I- D, has anti-tumor activity.

For research use only. We do not sell to patients.

Cdc7-IN-6 Chemical Structure

Cdc7-IN-6 Chemical Structure

CAS No. : 1402057-88-8

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Description

Cdc7-IN-6 (compound I-D) is a potent Cdc7 kinase inhibitor (IC50=4 nM), extracted from patent WO2019165473A1, compound I- D, has anti-tumor activity[1].

In Vitro

Cdc7-IN-6 demonstrates potent inhibitory activity (IC50<3 µΜ) in a range of solid tumor cell lines, including those of bladder (5673, RT1 12/84), sarcoma (143B, CADO-ES1, RD-ES, A673), colon and cecum (Colo-205, DLD-l, LS1034, SK-CO-l, SNU-C1), renal (U0.31), head-and-neck (CNE-2Z, RPMI-2650), melanoma (A2058, A875), and gastric (HGC-27) lineages[1].

Molecular Weight

465.43

Formula

C₂₁H₂₂F₃N₅O₄

CAS No.

1402057-88-8

SMILES

O=C(C(C/1=O)=C(NN2CCN(CC(F)(F)F)CC2)OC1=C/C3=CNC4=NC=CC=C43)OCC

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Cdc7-IN-6CDKCyclin dependent kinaseInhibitorinhibitorinhibit

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