1. PROTAC
    Cell Cycle/DNA Damage
  2. Ligands for Target Protein for PROTAC
    CDK
  3. Abemaciclib metabolite M18

Abemaciclib metabolite M18  (Synonyms: LSN3106729)

Cat. No.: HY-126534
Handling Instructions

Abemaciclib metabolite M18 (LSN3106729), the metabolite of Abemaciclib (HY-16297A), is a CDK inhibitor with antitumor activity. Abemaciclib metabolite M18 and a CRBN ligand have been used to design PROTAC CDK4/6 degrader.

For research use only. We do not sell to patients.

Abemaciclib metabolite M18 Chemical Structure

Abemaciclib metabolite M18 Chemical Structure

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Description

Abemaciclib metabolite M18 (LSN3106729), the metabolite of Abemaciclib (HY-16297A), is a CDK inhibitor with antitumor activity. Abemaciclib metabolite M18 and a CRBN ligand have been used to design PROTAC CDK4/6 degrader[1][2].

IC50 & Target[1]

CDK4

 

CDK6

 

In Vitro

Abemaciclib metabolite M18 hydrochloride exhibits T1/2 of 43.1 hr in plasma in healthy subjects[3].
CDK4/6 inhibitors’ chief mechanism of action is inhibition of retinoblastoma (RB) protein phosphorylation and thus the induction of cell cycle arrest, CDK4/6 inhibitors alter cancer cell biology in other ways[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CDK4/6 inhibitors results T-cell persistence and immunologic memory increasing in mice receiving tumor-specific CD8+ T cells[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

494.54

Formula

C25H28F2N8O

SMILES

FC(C=N1)=C(C2=CC(N(C(C)C)C(CO)=N3)=C3C(F)=C2)N=C1NC4=NC=C(C=C4)CN5CCNCC5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Abemaciclib metabolite M18
Cat. No.:
HY-126534
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