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CDK9/10/GSK3β-IN-1 

Cat. No.: HY-151375
Handling Instructions

CDK9/10/GSK3β-IN-1 (compound 13c) is a kinase inhibitor (Flavopiridol (HY-10005) analogue) that effectively inhibits HsGSK3β (IC50=59 nM), HsCDK9/CyclinT (IC50=64 nM), HsCDK5/p25 (IC50=1.093 µM) and HsCDK2/CyclinA (IC50=1.725 µM). CDK9/10/GSK3β-IN-1 has anti-cancer cellular activity comparable to or higher than that of Flavopiridol. CDK9/10/GSK3β-IN-1 shows high anti-proliferative activity in vitro against up to seven cancer cell lines.

For research use only. We do not sell to patients.

CDK9/10/GSK3β-IN-1 Chemical Structure

CDK9/10/GSK3β-IN-1 Chemical Structure

CAS No. : 2423045-06-9

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Description

CDK9/10/GSK3β-IN-1 (compound 13c) is a kinase inhibitor (Flavopiridol (HY-10005) analogue) that effectively inhibits HsGSK3β (IC50=59 nM), HsCDK9/CyclinT (IC50=64 nM), HsCDK5/p25 (IC50=1.093 µM) and HsCDK2/CyclinA (IC50=1.725 µM). CDK9/10/GSK3β-IN-1 has anti-cancer cellular activity comparable to or higher than that of Flavopiridol. CDK9/10/GSK3β-IN-1 shows high anti-proliferative activity in vitro against up to seven cancer cell lines[1].

IC50 & Target

IC50: 59 nM (HsGSK3β), 64 nM (HsCDK9/CyclinT), 1.093 µM (HsCDK5/p25), 1.725 µM (HsCDK2/CyclinA)[1].

In Vitro

CDK9/10/GSK3β-IN-1 (series concentration,72 h) exhibits high antiproliferative activity to SKOV3, NCIeN87, SKBR3, PC3, MiaPaCa-2, HCT116, K562 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: SKOV3, NCIeN87, SKBR3, PC3, MiaPaCa-2, HCT116, K562 cells
Concentration: Series concentration
Incubation Time: 72 h
Result: Showed high antiproliferative activity, with an IC50 < 100 nM on 6 cancer cell lines, and up to six times more potent on the pancreatic cancer cells (MiaPaCa-2) than the reference compound, flavopiridol.
Molecular Weight

546.04

Formula

C29H24ClN3O4S

CAS No.
SMILES

ClC1=CC(SC2=NC3=CC=CC=C3N2C)=CC=C1C(OC4=C5C(O)=CC(O)=C4C(CC6)=CCN6C)=CC5=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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CDK9/10/GSK3β-IN-1
Cat. No.:
HY-151375
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