2. Cefilavancin

Cefilavancin (TD-1792) is a potent multivalent glycopeptide-cephalosporin heterodimer antibiotic with effective activity against Gram-positive bacteria. Cefilavancin has been used to research skin infections.

For research use only. We do not sell to patients.

Cefilavancin Chemical Structure

Cefilavancin Chemical Structure

CAS No. : 1393900-12-3

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Cefilavancin Related Antibodies

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Description

Cefilavancin (TD-1792) is a potent multivalent glycopeptide-cephalosporin heterodimer antibiotic with effective activity against Gram-positive bacteria. Cefilavancin has been used to research skin infections[1][2][3].

IC50 & Target

Bacteria, antibiotic[1]
In Vitro

Cefilavancin (TD-1792) has highly active against Methicillin-susceptible Staphylococcus aureus (MIC90 = 15 ng/mL), Methicillin-resistant Staphylococcus aureus, and heterogeneous Vancomycin-intermediate Staphylococcus aureus (MIC90 = 30 ng/mL)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cefilavancin Related Antibodies
In Vivo

Cefilavancin (0.03-10 mg/kg; s.c.) produces a dose-dependent reduction of thigh bacterial burden in infected mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female NSA mice (18-30 g; neutropenia induced by administering cyclophosphamide, then injected bacteria into the posterior thigh)[3]
Dosage: 0.03-10 mg/kg
Administration: s.c.; single dosage (every 24 h) or two (every 12 h), three (every 8 h), or four (every 6 h) divided doses
Result: Produced a maximal of approximately 1- to 2-log10 kill against MRSA ATCC 33591, MSSA ATCC 29213, and MRSE MED 820 and ≥3-log10 kill against VISA HIP 5836, MSSE SU03, PSSP MED35, PSSP MED1119, and Streptococcus pyogenes MED 2040 strains.
Molecular Weight

1983.26

Formula

C87H95Cl3N16O28S2
CAS No.
SMILES

[O-]C(C1=C(C[N+]2=CC=CC=C2)CS[C@@]([C@@H]3NC(/C(C4=C(SC(N)=N4)Cl)=N\OCCCNC([C@@H]5C6=CC(O)=CC(O)=C6C7=CC([C@]8([H])C(N[C@]([C@@H](C9=CC=C(OC%10=CC([C@](NC([C@@H](NC([C@@H]([C@@H](C%11=CC=C(O%12)C(Cl)=C%11)O)NC([C@H](NC)CC(C)C)=O)=O)CC(N)=O)=O)([H])C(N8)=O)=CC%12=C%10O[C@H]%13[C@@H]([C@H]([C@@H]([C@H](O%13)CO)O)O)O[C@H]%14C[C@](N)([C@@H]([C@@H](O%14)C)O)C)C(Cl)=C9)O)([H])C(N5)=O)=O)=CC=C7O)=O)=O)([H])N1C3=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cefilavancin1393900-12-3TD-1792TD1792TD 1792Inhibitorinhibitorinhibit

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