1. Epigenetics
    Cell Cycle/DNA Damage
  2. Epigenetic Reader Domain
    CRISPR/Cas9
  3. CEM114

CEM114 

Cat. No.: HY-136572
Handling Instructions

CEM114 is an effective chemical epigenetic modifier (CEM) that recruits endogenous chromatin machinery through CRISPR-Cas9 systems.

For research use only. We do not sell to patients.

CEM114 Chemical Structure

CEM114 Chemical Structure

CAS No. : 2279062-54-1

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Description

CEM114 is an effective chemical epigenetic modifier (CEM) that recruits endogenous chromatin machinery through CRISPR-Cas9 systems[1].

In Vitro

CEM114 (200 nM; 48 hours) treatment significantly activates the Green Fluorescent Protein (GFP) signal, suggesting that excess FK506 is able to outcompete CEM114 from the FKBP binding site[1].

Cell Viability Assay[1]

Cell Line: HEK 293T cells
Concentration: 200 nM
Incubation Time: 48 hours
Result: Significantly activated the GFP signal.
Molecular Weight

1612.98

Formula

C₈₄H₁₂₂FN₉O₁₉S

CAS No.

2279062-54-1

SMILES

CC1=NOC(C)=C1C2=CC=C(C3=C2)N(C(CCC(C=C4)=CC(F)=C4OCC(N=N5)=CN5CCOCCOCCOCCNC(CCSCCC[[email protected]](/C=C(C[[email protected]@H](C[[email protected]@H]([[email protected]](O[[email protected]]6(C7=O)O)([H])[[email protected]](C[[email protected]]6C)OC)OC)C)\C)C(C[[email protected]@H]([[email protected]]([[email protected]](OC([[email protected]@](CCCC8)([H])N8C7=O)=O)/C(C)=C/[[email protected]](CC[[email protected]]9O)C[[email protected]]9OC)C)O)=O)=O)=N3)CCN%10CCOCC%10

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Keywords:

CEM114CEM 114CEM-114Epigenetic Reader DomainCRISPR/Cas9chemicalepigeneticmodifiersrecruitendogenouschromatinmachineryCRISPR-Cas9systemInhibitorinhibitorinhibit

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