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Products are for research use only. Not for human use. We do not sell to patients.
(CHR 6494; CHR6494)
CHR-6494 Chemical Structure
|Product name: CHR-6494|
|Cat. No.: HY-15217|
CHR-6494 is a potent and selective Haspin (Haploid Germ Cell-Specific Nuclear Protein Kinase) inhibitor that blocks H3T3ph phosphorylation.
IC50 Value: N/A
Target: Haspin Kinase
CHR-6494 is a first-in-class Haspin inhibitor with a wide spectrum of anticancer effects. Recent research showed that CHR-6494 reduces H3T3ph levels in a dose-dependent manner and causes a mitotic catastrophe characterized by metaphase misalignment, spindle abnormalities and centrosome amplification. From the cellular standpoint, the identified small-molecule Haspin inhibitor causes arrest in G2/M and subsequently apoptosis. Importantly, ex vivo assays also demonstrate its anti-angiogenetic features; in vivo, it shows antitumor potential in xenografted nude mice without any observed toxicity.
|M.Wt||292.34||Storage||Please store the product under the recommended conditions in the Certificate of Analysis.|
|Solvent & Solubility||
10 mM in DMSO
|1 mg||5 mg||10 mg|
|1 mM||3.4207 mL||17.1034 mL||34.2067 mL|
|5 mM||0.6841 mL||3.4207 mL||6.8413 mL|
|10 mM||0.3421 mL||1.7103 mL||3.4207 mL|
. Cuny, Gregory D.; Ulyanova, Natalia P.; Patnaik, Debasis et al. Structure-activity relationship study of beta-carboline derivatives as haspin kinase inhibitors. Bioorganic & Medicinal Chemistry Letters (2012), 22(5), 2015-2019.
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