Successful, we will reply to you quickly.OK
Please select the quantity.OK
Your message is being sent, please wait.Close
Send mail failed, please send again!Close
Products are for research use only. Not for human use. We do not sell to patients.
(CHR 6494; CHR6494)
CHR-6494 Chemical Structure
|Product name: CHR-6494|
|Cat. No.: HY-15217|
CHR-6494 is a potent and selective Haspin (Haploid Germ Cell-Specific Nuclear Protein Kinase) inhibitor that blocks H3T3ph phosphorylation.
IC50 Value: N/A
Target: Haspin Kinase
CHR-6494 is a first-in-class Haspin inhibitor with a wide spectrum of anticancer effects. Recent research showed that CHR-6494 reduces H3T3ph levels in a dose-dependent manner and causes a mitotic catastrophe characterized by metaphase misalignment, spindle abnormalities and centrosome amplification. From the cellular standpoint, the identified small-molecule Haspin inhibitor causes arrest in G2/M and subsequently apoptosis. Importantly, ex vivo assays also demonstrate its anti-angiogenetic features; in vivo, it shows antitumor potential in xenografted nude mice without any observed toxicity.
|M.Wt||292.34||Storage||Please store the product under the recommended conditions in the Certificate of Analysis.|
|Solvent & Solubility||
10 mM in DMSO
|1 mg||5 mg||10 mg|
|1 mM||3.4207 mL||17.1034 mL||34.2067 mL|
|5 mM||0.6841 mL||3.4207 mL||6.8413 mL|
|10 mM||0.3421 mL||1.7103 mL||3.4207 mL|
. Cuny, Gregory D.; Ulyanova, Natalia P.; Patnaik, Debasis et al. Structure-activity relationship study of beta-carboline derivatives as haspin kinase inhibitors. Bioorganic & Medicinal Chemistry Letters (2012), 22(5), 2015-2019.