Chrexanthomycin C 

Chrexanthomycin C is an orally active marine natural product with remarkable bioactivities. Chrexanthomycin C has binding affinity for DNA (G4C2)⁴ G4 with a K_d value of 2.8 mM. Chrexanthomycin C can be used for the research of neurodegenerative disease such as amyotrophic lateral sclerosis (ALS)^[1].

Kd: 2.8 mM (DNA (G4C2)⁴ G4)^[1]

Chrexanthomycin C (Compounds cC) (0.1-10 mM) binds DNA (G4C2)⁴ G4 with a K_d value of 2.8 mM^[1].
Chrexanthomycin C has good permeability, low cytotoxicity, and nonhemolytic activity^[1].
Chrexanthomycin C (1.57 μM) rescues G4C2 EHR-related pathologies in cells^[1].
Chrexanthomycin C selectively binds to DNA and RNA G4C2 G4s^[1].
Chrexanthomycin C (0-100 μM) dramatically reduceS G4C2 EHR-caused cell death, diminish G4C2 RNA foci in (G4C2)29-expressing Neuro2a cells, and significantly eliminate ROS in HT22 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chrexanthomycin C (Compounds cC) (fed; 100 μM) significantly rescues eye degeneration and improve locomotor deficits in (G4C2)29-expressing^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

636.51

C₃₁H₂₄O₁₅

CC(CC(C=C1CCC(C(O)=C(O2)C(C(C3=C2C(O[C@H](O4)[C@H](O)[C@@H](O)C(O)=C4C(O)=O)=CC=C3)=O)=C5O)=C5C1=C6O)=C6C(O)=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Aifang Cheng, et al. Selective C9orf72 G-Quadruplex-Binding Small Molecules Ameliorate Pathological Signatures of ALS/FTD Models. Journal of Medicinal Chemistry Article ASAP.