1. GPCR/G Protein
  2. Prostaglandin Receptor
  3. Cicaprost

Cicaprost (Synonyms: ZK 96480)

Cat. No.: HY-19583
Handling Instructions

Cicaprost (ZK 96480) is a prostacyclin receptor (IP) agonist. Cicaprost causes a concentration-dependent relaxation of the artery with an EC50 of 5.8 nM 。

For research use only. We do not sell to patients.

Cicaprost Chemical Structure

Cicaprost Chemical Structure

CAS No. : 94079-80-8

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Description

Cicaprost (ZK 96480) is a prostacyclin receptor (IP) agonist. Cicaprost causes a concentration-dependent relaxation of the artery with an EC50 of 5.8 nM [1]

In Vitro

Cicaprost significantly reduces proliferation of human pulmonary artery smooth muscle cells (HPASMC) stimulated by fetal bovine serum (FBS). Cicaprost displays marked antiproliferative activity at 30 nM[2].
Cicaprost stimulates [3H]cyclic AMP production with EC50 values of 1.5-22 nM, and stimulates [3H]inositol phosphate production (EC50 values 49-457 nM) in all but the SK-N-SH cells[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[2]

Cell Line: HPASMC
Concentration: 10 pM, 100 pM, 1 nM, 10 nM, 100 nM, 1 μM, and 10 μM
Incubation Time:
Result: Dose-dependently inhibited proliferation with an EC50 of 24.1 nM.
In Vivo

Cicaprost alters pain perception and inflammatory response in mice lacking prostacyclin receptor. Intravenous injection of Cicaprost (1 μg/kg) causes hypotension of ∼30 mm Hg in anaesthetized wild-type mice[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wild-type (+/+) and IP−/− mice[4]
Dosage: 1 μg/kg
Administration: Intravenous injection
Result: Caused hypotension of ∼30 mm Hg in anaesthetized wild-type mice, whereas there was no change in blood pressure in IP-deficient mice even at 10 μg/kg.
Molecular Weight

374.47

Formula

C22H30O5

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Cicaprost
Cat. No.:
HY-19583
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