1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)

Cilomilast (Synonyms: SB-207499)

Cat. No.: HY-10790 Purity: 98.81%
Handling Instructions

Cilomilast(SB 207499; Ariflo) is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity.

For research use only. We do not sell to patients.

Cilomilast Chemical Structure

Cilomilast Chemical Structure

CAS No. : 153259-65-5

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 106 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
5 mg USD 96 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
10 mg USD 168 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
50 mg USD 552 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
100 mg USD 972 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Cilomilast(SB 207499; Ariflo) is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity. IC50 value: 110 nM Target: PDE 4 Cilomilast (SB-207499) inhibits HPDE4 and LPDE4 catalytic activity with equal potency (Ki ≈100 nM). SB-207499 and rolipram are equipotent against LPDE4, but Cilomilast (Ariflo, SB-207499) is 100-fold less potent against HPDE4. This profile suggests that Cilomilast (Ariflo, SB-207499) retain the anti-inflammatory activity of rolipram yet have a decreased tendency to produce side effects.

Clinical Trial
Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9119 mL 14.5594 mL 29.1189 mL
5 mM 0.5824 mL 2.9119 mL 5.8238 mL
10 mM 0.2912 mL 1.4559 mL 2.9119 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

343.42

Formula

C₂₀H₂₅NO₄

CAS No.

153259-65-5

SMILES

O=C([[email protected]]1CC[[email protected]@](C#N)(CC1)C2=CC=C(OC)C(OC3CCCC3)=C2)O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Cilomilast
Cat. No.:
HY-10790
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Cilomilast

Cat. No.: HY-10790