1. Metabolic Enzyme/Protease
  2. Adenosine Deaminase
  3. Cladribine

Cladribine (Synonyms: 2-Chloro-2′-deoxyadenosine; CldAdo; 2CdA)

Cat. No.: HY-13599 Purity: 99.89%
Handling Instructions

Cladribine is an adenosine deaminase inhibitor used to treat hairy cell leukemia and multiple sclerosis.

For research use only. We do not sell to patients.

Cladribine Chemical Structure

Cladribine Chemical Structure

CAS No. : 4291-63-8

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
10 mg USD 60 In-stock
Estimated Time of Arrival: December 31
50 mg USD 84 In-stock
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100 mg USD 132 In-stock
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Customer Review

Based on 3 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Cladribine purchased from MCE. Usage Cited in: Chem Pharm Bull (Tokyo). 2017 Aug 1;65(8):768-775.

    Changes in Bcl-2 protein expression in MCF-7 cells after treatment with Cladribine, Dasatinib or Gefitinib alone or in combination for 12 h. Expression of Bcl-2 protein is analyzed by western blotting analysis.
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    Description

    Cladribine is an adenosine deaminase inhibitor used to treat hairy cell leukemia and multiple sclerosis. Target: Adenosine Deaminase Cladribine possesses concentration-dependent apoptosis-inducing potential in the HSB2 cells. Cladribine inhibits growth of primary mast cell (MC) and the MC line HMC-1 in a dose-dependent manner, with lower IC50 values recorded in HMC-1.2 cells harboring KIT D816V compared to HMC-1.1 cells lacking KIT D816V. Cladribine (0.7-3.5 mM) and/or diltiazem (2.4 mM), is injected intraperitoneally into adult zebrafish and red blood cell (RBC) lysates are assayed by HPLC for levels of purine nucleotides (e.g. ATP), potential biomarkers of cardiovascular health. Diltiazem increased RBC ATP concentrations, which are inhibited by co-injection of cladribine.

    Clinical Trial
    Molecular Weight

    285.69

    Formula

    C₁₀H₁₂ClN₅O₃

    CAS No.

    4291-63-8

    SMILES

    OC[[email protected]@H]1[[email protected]](C[[email protected]](N2C=NC3=C2N=C(Cl)N=C3N)O1)O

    Shipping

    Room temperature in continental US; may vary elsewhere

    Storage

    4°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 30 mg/mL (105.01 mM)

    H2O : 10 mg/mL (35.00 mM; Need ultrasonic)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.5003 mL 17.5015 mL 35.0030 mL
    5 mM 0.7001 mL 3.5003 mL 7.0006 mL
    10 mM 0.3500 mL 1.7501 mL 3.5003 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References

    Purity: 99.89%

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    Product Name:
    Cladribine
    Cat. No.:
    HY-13599
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