1. Membrane Transporter/Ion Channel
  2. P-glycoprotein
  3. Coleon-U-quinone

Coleon-U-quinone 

Cat. No.: HY-N10563
Handling Instructions

Coleon-U-quinone is a potent P-gp inhibitor. Coleon-U-quinone can inhibit cancer cells viability and sensitize multidrug resistance cancer cells to Doxorubicin (HY-15142A).

For research use only. We do not sell to patients.

Coleon-U-quinone Chemical Structure

Coleon-U-quinone Chemical Structure

CAS No. : 65714-83-2

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Description

Coleon-U-quinone is a potent P-gp inhibitor. Coleon-U-quinone can inhibit cancer cells viability and sensitize multidrug resistance cancer cells to Doxorubicin (HY-15142A)[1].

IC50 & Target

P-glycoprotein[1]

In Vitro

Coleon-U-quinone (0-50 μM; 72 h) has inhibitory activity against NCI-H460, NCI-H460/R and MRC-5[1].
Coleon-U-quinone (1-5 μM; 72 h) sensitize NCI-H460/R cells to Doxorubicin (HY-15142A)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: NCI-H460, NCI-H460/R and MRC-5
Concentration: 0-50 μM
Incubation Time: 72 h
Result: Exhibited inhibitory activity against NCI-H460, NCI-H460/R and MRC-5 with IC50s of 22.96 ± 0.56 μM, 20.37 ± 0.43 μM and 44.13 ± 1.19 μM.

Cell Proliferation Assay[1]

Cell Line: NCI-H460/R
Concentration: 1, 2 and 5 μM
Incubation Time: 72 h
Result: Sensitized NCI-H460/R cells to Doxorubicin (HY-15142A) with IC50s of 0.565 μM, 0.482 μM and 0.217 μM at 1 μM, 2 μM and 5 μM, respectively.
Molecular Weight

344.40

Formula

C20H24O5

CAS No.
SMILES

O=C(C1=C2[[email protected]@](CCCC3(C)C)(C3=C(C1=O)O)C)C(C(C)C)=C(O)C2=O

Structure Classification
Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Coleon-U-quinone
Cat. No.:
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