Colletofragarone A2 

Colletofragarone A2 can be be isolated from the fungus Colletotrichum sp. (13S020). Colletofragarone A2 inhibits mutant p53 and HSP90 with anti-cancer activity. Colletofragarone A2 promotes degradation and aggregation of mutant p53 and suppressing tumor growth in vivo^[1].

Mutant p53 loses original tumor suppressor function but acquires new abilities regarding oncogenic progression^[1].
Colletofragarone A2 (0.05-5 μM; 72 h) shows high selectivity and more cytotoxic activity on cells with p53^R175H structural mutants than with other p53 statuses such as a DNA-contact mutant, wild-type, and null cells^[1].
Colletofragarone A2 (2 μM; 8 h) decreases mutant p53 levels in SK-BR-3 (p53^R175H) cells by promoting p53 degradation^[1].
Colletofragarone A2, combinded with 10 μM MG-132 (HY-13259), (2 or 4 μM; 4 h) induces the accumulation of the aggregated mutant p53^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Colletofragarone A2 (0.35 mM, 100 μL; injected intratumorally and daily; 13 d) markedly decreases tumor cell growth in mouse infected with HuCCT1 (p53^R175H) cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

386.44

C₂₂H₂₆O₆

181377-06-0

C/C=C/C=C/C=C/C1=C2[C@@]3([H])[C@@](C=CC([C@@]3([H])[C@H](O)C[C@H](O)C[C@H](C)OC2=O)=O)([H])O1

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• [1]. Sadahiro Y, et al. Colletofragarone A2 Inhibits Cancer Cell Growth In Vivo and Leads to the Degradation and Aggregation of Mutant p53. Chem Res Toxicol. 2022 Aug 26.   [Content Brief]